Clinical Evaluation of the Postoperative Pain and Substance P levels Following the use of Bioceramic verses Calcium Hydroxide Intracanal Medicaments in Permanent Mandibular molars with Symptomatic Apical Periodontitis
- Patients aged 18-45 years with no sex predilection
Medically free Patients with no systemic conditions that can affect post operative pain response.
Patients should not be taking any pain medications 24 hours before intervention
Positive patients' acceptance for participating in the study
- Medically compromised patients
Patients who have received antibiotic therapy within the last 2 weeks.
Pregnant or lactating women.
Patients with known allergy to any of the irrigants used.
Parallel
Calcium Hydroxide (Ca(OH)2)
DrugCalcium hydroxide will be used as an intracanal medicament during root canal treatment in Permanent Mandibular molars with Symptomatic Apical Periodontitis
Bioceramic Intracanal Medicament
DrugBioceramic material will be used as an intracanal medicament during root canal treatment in Permanent Mandibular molars with Symptomatic Apical Periodontitis
Assessment of postoperative pain levels
Postoperative pain intensity will be assessed using the Visual Analog Scale (VAS), ranging from 0 to 10, where 0 indicates no pain and 10 indicates the worst imaginable pain. Pain scores will be recorded at 6 hours, 24 hours, 48 hours, 72 hours, and 7 days after treatment to compare postoperative pain levels between the two medicament groups and evaluate the correlation between Substance P reduction and pain perception.
neurogenic biomarker Substance P Level
To compare the effectiveness of bio ceramic intracanal medicament (Bio-C Temp) and calcium hydroxide in reducing the neurogenic biomarker Substance P in periapical samples of molars diagnosed with symptomatic apical periodontitis
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