Systemic inflammation and intestinal hyperpermeability (disruption of the gut barrier which allows nutrient molecules and bacteria to enter the bloodstream) are triggered by consumption of high-sugar meals and are linked to future development of cardiovascular disease (CVD). Previous research indicates that fresh mangos have properties that have positive effects on the intestinal barrier and local gut inflammation. The investigators want to understand if replacing table sugar (sucrose) with sugar from fresh mango (which also contains fiber and plant bioactives) will lead to decreased inflammatory and permeability biomarkers after eating a high-sugar breakfast. The investigators will compare the postprandial (post meal) levels of inflammatory (IL-6) and permeability (LPS, lipid binding protein (LBP), and soluble CD14) biomarkers in blood from participants who have consumed a meal sweetened with either sucrose or fresh mango.
18 - 45 years.
Body mass index between 18.5-35.0 kg/m2
Not pregnant or expecting to become pregnant (females only)
Not postmenopausal (females only).
Not between the ages of 18-45
Body mass index < 18.5 kg/m2 or >35.0 kg/m2
Pregnant (females only)
Postmenopausal status (females only).
Crossover
High-Glycemic Breakfast Containing Cereal and Fresh Mango
Other interventionHigh-glycemic breakfast of 84 grams of corn flakes prepared with 355 mL of 2% milk and sweetened with 262 grams of fresh mango.
High-Glycemic Breakfast Containing Cereal and Table Sugar
Other interventionHigh-glycemic breakfast of 84 grams of corn flakes prepared with 355 mL of 2% milk and sweetened with 36 grams of table sugar.
LPS
The investigators will measure LPS at baseline and 30-, 60-, 120-, and 180- minutes after each meal. These measurements will take place immediately and a complete dataset will be compiled upon study completion.
LPS Binding Protein
The investigators will measure LPS binding protein at baseline and 30-, 60-, 120-, and 180-minutes after each meal. These measurements will take place immediately and a complete dataset will be compiled upon study completion.
IL-6
The investigators will measure IL-6 at baseline and 30-, 60-, 120-, and 180-minutes after each meal. These measurements will take place immediately and a complete dataset will be compiled upon study completion.
sCD14
The investigators will measure soluble CD14 at baseline and 30-, 60-, 120-, and 180-minutes after each meal. These measurements will take place immediately and a complete dataset will be compiled upon study completion.
Acceptability
The investigators will measure acceptability of each meal with a survey at each study visit once post-meal.
Satiety
The investigators will measure satiety through a survey at baseline and at 30-, 60-, 90-, 120-, 150-, and 180-minutes after the meal.
Body Composition
The investigators will measure body composition using bioelectrical impedance (InBody).
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Ball State University
Lead sponsor
National Mango Board
Collaborator
