The objective of this study is to determine the prevalence of asymptomatic viral carriers among healthy surgical patients and to describe the demographic and clinical characteristics of these patients. The secondary objective is to compare the incidence of perioperative respiratory adverse events (PRAE) between virus positive patients with and without upper respiratory infection (URI) symptoms. The secondary objective would aim to enroll patients who report recent URI symptoms.
Patients <18 years of age presenting for elective ambulatory procedures under general anesthesia at NCH. Patient will either identify as asymptomatic or have had URI symptoms currently or within the past two weeks.
Chronic medical problems (excluding asthma), diagnosis of cancer, transplant recipient, receiving immunomodulatory medications (cyclosporine, tacrolimus, azathioprine, mycophenolate, monoclonal AB, lithium), or currently prescribed antibiotics.
Patients \<18 presenting at NCH for elective ambulatory procedures under general anesthesia. 100 patients who are asymptomatic for URI symptoms 200 patients who report recent (within 2 weeks) or current URI symptoms.
Case-control
Prospective
Mid-turbinate nasal swab
Diagnostic testMid-turbinate nasal swab for viral testing using a PCR film array test (qRT-PCR).
Result from mid-turbinate nasal swab to test of viruses that cause URI by qRT-PCR test.
All patients will be tested for the presence of viruses that cause upper respiratory infections by taking a mid-turbinate nasal swab and using a PCR film array test.
Association between asymptomatic viral infections and perioperative respiratory adverse events (PRAEs).
Occurrence of PRAE during or after surgery.
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Brittany Willer
Lead sponsor
Nationwide Children's Hospital
Sponsor institution
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