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Pre-induction Norepinephrine in Septic Patients Undergoing Surgery

ConditionsSepsisHypotension
Trial statusNot yet recruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-65
SponsorAssiut University

About this trial

This randomized controlled trial aims to evaluate the effect of early pre-induction norepinephrine infusion on perioperative hemodynamic stability in septic patients with SOFA score ≥2 undergoing surgery under general anesthesia.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

- Age 18 to 65 years

Diagnosed with severe sepsis with SOFA score ≥2

Scheduled for surgery under general anesthesia

ASA physical status III or IV

Disqualifiers

Severe pre-existing cardiovascular compromise

Known allergy or hypersensitivity to norepinephrine

Pregnancy or lactation

Refusal to participate

Trial design

Design model

Parallel

Treatments tested in this trial

  • Norepinephrine

    Drug

    Continuous intravenous infusion of norepinephrine.

Treatment groups

90 Participants
are divided into 2 treatment groups
Group A: Early NorepinephrineExperimental treatment 1 intervention
Group B: ControlActive comparator 1 intervention

Trial outcomes

Primary outcomes

1

Incidence of post-induction hypotension

Number of patients with mean arterial pressure drop greater than 20% from baseline or mean arterial pressure less than 65 mmHg within the first 30 minutes after induction of general anesthesia.

Time frame
Periprocedurally

Secondary outcomes

1

Mean arterial pressure

Mean arterial pressure in mmHg.

Time frame
Periprocedurally
2

Total dose of rescue vasopressors

Mean total dose of rescue vasopressors administered intraoperatively in micrograms.

Time frame
Immediately after the intervention/procedure/surgery
3

Total volume of intravenous fluids

Mean total volume of intravenous fluids administered intraoperatively in milliliters.

Time frame
Immediately after the intervention/procedure/surgery
4

Length of ICU stay

Mean length of intensive care unit stay in days.

Time frame
At 28 days

Other outcomes

Locations

This trial has no locations.

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Assiut University

Lead sponsor

Source ClinicalTrials.gov

This trial is not recruiting at the moment. You can still explore other options: