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Pre-Sleep Creatine Enhances Anaerobic Power in Recreationally Active Females

ConditionsAnaerobic PerformanceSports NutritionExercise RecoveryMuscle FatigueCreatine SupplementationRecreational Physical ActivityFemale Athletes
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexFemale
Age18-25
SponsorAnkara Yildirim Beyazıt University

About this trial

This study is a randomized, double-blind, placebo-controlled trial designed to examine the effects of pre-sleep creatine monohydrate supplementation on anaerobic performance and muscle damage markers in recreationally active females. Participants will be randomly assigned to receive either 5 grams of creatine monohydrate or a placebo 30 minutes before sleep for seven consecutive days. Anaerobic performance will be assessed using the Wingate Anaerobic Test, evaluating peak and average power output and fatigue index. Blood samples will be collected before and after the supplementation period to analyze markers of muscle damage, including creatine kinase and lactate dehydrogenase. This study aims to provide insight into the efficacy of short-term, time-specific creatine supplementation for enhancing performance and recovery.

Eligibility criteria

This trial accepts healthy volunteers

Qualifiers

None

Disqualifiers

None

Trial design

Design model

Parallel

Treatments tested in this trial

  • Creatine Monohydrate

    Dietary supplement

    Participants will receive 5 grams of creatine monohydrate powder dissolved in water, flavored with a sugar-free agent, 30 minutes before sleep each night for 7 days.

  • Placebo (Maltodextrin)

    Dietary supplement

    Visually identical placebo (maltodextrin powder, 5 g/day), flavored with a sugar-free agent, dissolved in water and consumed 30 minutes before sleep for 7 consecutive days.

Treatment groups

24 Participants
are divided into 2 treatment groups
Group A: Creatine Monohydrate SupplementationExperimental treatment 1 intervention
Group B: Placebo SupplementationPlacebo comparator 1 intervention

Trial outcomes

Primary outcomes

1

Average Power Output (Watts) - 30-Second Wingate Test

Average anaerobic power output will be calculated across the 30-second Wingate cycling test.

Time frame
Baseline and post-intervention (Day 0 and Day 7)

Secondary outcomes

1

Peak Power Output (Watts) - Wingate Test

Peak power output during the initial 5 seconds of the 30-second Wingate cycling test.

Time frame
Baseline and post-intervention (Day 0 and Day 7)
2

Fatigue Index (%) - Wingate Test

Calculated as the percent drop in power from peak to minimum power output during the 30-second Wingate test, indicating fatigue rate.

Time frame
Baseline and post-intervention (Day 0 and Day 7)
3

Serum Creatine Kinase (CK) Activity

Serum creatine kinase activity will be measured as a marker of muscle damage using a spectrophotometric assay.

Time frame
Baseline and 24 hours post Wingate Test (Day 0 and Day 8)
4

Serum Lactate Dehydrogenase (LDH) Activity

Serum lactate dehydrogenase activity will be measured as an indicator of cell membrane permeability and muscle damage using spectrophotometry.

Time frame
Baseline and 24 hours post Wingate Test (Day 0 and Day 8)

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Ankara Yildirim Beyazıt University

Lead sponsor

Source ClinicalTrials.gov
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