Physical exercise, particularly strength training, has become an effective strategy to improve physical function, muscle mass, and quality of life in cancer patients. However, the biological mechanisms underlying these benefits remain poorly understood, especially during active treatment. The PEPOH project (Precision physical Exercise for Personalized Onco-Hematology) proposes a single-center clinical trial conducted at the Fundación del Instituto de Investigación Biomédica de Salamanca (FIBSAL) including five different patient cohorts: lung, colorectal (CRC), and breast cancer, chronic lymphocytic leukemia, and multiple myeloma. Participants will be randomly assigned to either an in-person intervention group, performing a supervised strength training program twice a week for 12 weeks combined with a home-based exercise program, or a control group performing only the home-based program. Biological samples will be collected before and after the intervention for multi-dimensional characterization (Genomics, Transcriptomics, Proteomics and Metabolomics) and systematic integration with parameters of functional capacity, quality of life, psychological well-being, frailty, and body composition. The main objective of the project is to determine biological parameters associated with strength exercise and their relationship with clinical parameters related to prognosis, therapy response and survival. This multi-dimensional approach will enable the detection of exercise adaptation biomarkers and generate knowledge about the mechanisms linking exercise with improved health outcomes in individuals with cancer. PEPOH will contribute to biomedical science and will enhance the comprehensive care of oncohematologic patients by integrating multi-omic and clinical data into a precision exercise model. This project will also contribute to society by offering a cost-effective, safe, and transferable intervention, which increases the overall quality of life.
Adult patients (≥18 years), capable of signing the informed consent and willing to participate in the study.
Performance status (ECOG) 0-2.
Presence of unstable bone metastases or extensive bone involvement associated with a high risk of fracture.
Uncontrolled cardiovascular, respiratory, musculoskeletal, or metabolic diseases that contraindicate physical exercise at the investigator's discretion.
Explicit medical contraindication to exercise training.
Documented poor adherence (<80%).
Parallel
Supervised Intervention
Other interventionA strength training programme conducted twice per week for 12 weeks under professional supervision, complemented by a home-based exercise programme.
Home-based Intervention
Other interventionA home-based exercise programme following the same recommendations and guidelines as a supervised group but without supervised in-person sessions.
Functional physical condition
Dynamometry and Short Physical Performance Battery scale
Psychological well-being and mental health
Mensured using Hospital anxiety and depression scale
Determination of body composition
Body composition will be me asures using Tamita BC-418
Sleep quality
Atenas scale will be used
Overall Quality of life
European Organization for the Research and Treatment of Cancer Quality of Life Questionnaire will be used
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