Predicting Responses to Exhausting, Prolonged, And Repeated Exercise Demands (PREPARED) for Heat
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-39
SponsorState University of New York at Buffalo
About this trial
The overall goal of this project is to identify a work/rest cycle that allows for faster mission completion needed in emergency situations, compared to current Army heat guidance, while mitigating heat strain and neuromuscular fatigue. This project will determine the trade-off between faster mission completion and risk of heat strain and physical performance decrements. Completion of this project will allow military leaders to make informed decisions by understanding the impact of their choices on the magnitude of physical performance decrements and expected heat casualties, setting up hot weather missions for success.
Eligibility criteria
This trial accepts healthy volunteersQualifiers
Healthy individuals
Physically active
Disqualifiers
History of cardiovascular, metabolic (such as clinical thyroid disease), respiratory, neural, or renal disease
Hypertensive (systolic blood pressure > 139 mmHg, diastolic blood pressure > 89 mmHg) or tachycardic (heart rate > 100 bpm) during the screening visit
Taking medications or supplements known to effect physiologic responses to exercise or thermoregulation (e.g., beta blockers, omega-3 fatty acids, statins, aspirin)
Tobacco or nicotine use currently or in the past six months
Trial design
Design model
Crossover
Treatments tested in this trial
30/30 work/rest cycle
Other interventionParticipants will walk on a treadmill while wearing a weighted backpack to a work/rest cycle of 30 minutes of work followed by 30 minutes of rest.
30/20 work/rest cycle
Other interventionParticipants will walk on a treadmill while wearing a weighted backpack to a work/rest cycle of 30 minutes of work followed by 20 minutes of rest.
40/30 work/rest cycle
Other interventionParticipants will walk on a treadmill while wearing a weighted backpack to a work/rest cycle of 40 minutes of work followed by 30 minutes of rest.
20/12 work/rest cycle
Other interventionParticipants will walk on a treadmill while wearing a weighted backpack to a work/rest cycle of 20 minutes of work followed by 12 minutes of rest.
Treatment groups
24 Participants
are divided into 4 treatment groupsGroup A: 30/30 work/rest cycle firstActive comparator 4 interventions
Group B: 30/20 work/rest cycle firstExperimental treatment 4 interventions
Group C: 40/30 work/rest cycle firstExperimental treatment 4 interventions
Group D: 20/12 work/rest cycle firstExperimental treatment 4 interventions
Trial outcomes
Primary outcomes
1
Core temperature
Maximum gastrointestinal temperature reached during the work protocol
Time frame
180 minutes of work2
Isometric mid-thigh pull strength
Maximum voluntary contraction strength assessed using a force plate
Time frame
180 minutes of workSecondary outcomes
1
Metabolic cost
Collected expired air using a one-way mask will be analyzed using a metabolic cart to calculate metabolic heat production
Time frame
180 minutes of work2
Heart rate
Maximum heart rate measured using a telemetry strap throughout the work protocol
Time frame
180 minutes of work3
Mean skin temperature
Maximum skin temperature measured using buttons at four skin sites
Time frame
180 minutes of work4
Vastus lateralis electromyography
Wireless electromyography electrodes placed lengthwise over the vastus lateralis muscle belly
Time frame
180 minutes of workSponsors and contacts
Click on the lead sponsor to view all of their trials.
State University of New York at Buffalo
Lead sponsor
United States Department of Defense
Collaborator
Source ClinicalTrials.gov