Predicting Vital Pulp Treatment Outcomes in Symptomatic Pulpits Using Metabolic Biomarker
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age16-50
SponsorAbeer Ghalib Abdul-khaliq
About this trial
This prospective controlled clinical trial investigates whether metabolic biomarkers measured in pulpal blood at the time of carious pulp exposure can predict the 12-month outcomes of vital pulp treatment in symptomatic permanent teeth. Eligible patients aged 16-50 years presenting with deep carious pulp exposure will undergo vital pulp therapy (partial pulpotomy or full pulpotomy). Pulpal blood samples will be collected at the time of exposure and analyzed using High-Performance Liquid Chromatography (HPLC). Treatment outcomes will be assessed clinically and radiographically at 12 months. The study aims to identify objective, measurable biomarkers that can improve pulpal diagnosis and guide clinical decision-making in vital pulp therapy.
Eligibility criteria
This trial accepts healthy volunteersQualifiers
Age range of 16-50 years.
Pulp exposure during treatment of deep caries.
Absence of periodontitis or systemic disease.
Only one or two proximal surfaces lost with remaining walls > 2 mm; and
Disqualifiers
Teeth with unrestorable large defects or the need for RCT for aesthetic reasons;
Teeth with a negative response to cold testing
Current pregnancy or breastfeeding;
Poor compliance or inability to complete the trial.
Trial design
Design model
Single group
Treatments tested in this trial
vital pulp treatment
Procedure/SurgeryVital pulp treatment (VPT) is defined by the European Society of Endodontology as a group of biologically based procedures aimed at preserving the health and function of the dental pulp that has been exposed or is at risk of exposure. These procedures involve removal of infected or inflamed tissue where necessary, protection of the remaining vital pulp with a biocompatible material, and placement of a definitive restoration to achieve a hermetic seal and support healing.
Treatment groups
60 Participants
are divided into 1 treatment groupGroup A: Vital Pulp Treatment (VPT)Experimental treatment 1 intervention
Trial outcomes
Primary outcomes
1
Pulp survival: is overall clinical success at 12 months
Pulp survival: is overall clinical success at 12 months, defined according to COS-ENDO domains as the absence of patient-reported pain, absence of clinical signs of infection, maintenance of normal periradicular status radiographically, preservation of functional tooth structure, and no need for further intervention.
Time frame
From enrollment to the end of 12 months follow-upSponsors and contacts
Click on the lead sponsor to view all of their trials.
Abeer Ghalib Abdul-khaliq
Lead sponsor
University of Baghdad
Sponsor institution
Source ClinicalTrials.gov