As with other nutritional strategies, the clinical response to bariatric surgery can be highly variable, with weight regain being a frequent occurrence. Recent evidence on anti-obesity medication indicate similar inter-individual variability in clinical response. Among multiples factors, co-occurrence of eating disorders such as binge eating disorder has been implicated in insufficient clinical response. Improving our ability to predict how patients will respond to obesity treatment is necessary in order to tailor the care pathways we offer. The mechanisms involved in disturbances of eating behaviour before and after surgery remain largely unknown. This study aims to identify the predictive factors of weight loss after pharmacological or surgical treatment, as well as the cognitive and biological mechanisms that mediate this effect.
Age between 18 and 65 years
Obesity, with bariatric surgery indicated after a multidisciplinary evaluation in case of surgical treatment.
Good physical and mental health, enabling informed consent.
French speaker
Legal protection
Pregnancy or breastfeeding
History of bariatric surgery (except gastric banding, provided it was removed more than five years ago).
Acute or progressive chronic disease
Participants initiating an anti-obesity medication or candidates for bariatric surgery once its indication has been validated by a multidisciplinary committee, following medical, nutritional and psychological evaluations.
Cohort
Prospective
Pharmacological or surgical treament of obesity
Procedure/SurgeryLongitudinal follow-up of participants who initiate an anti-obesity medication or whose application for bariatric surgery was accepted. It will combine anthropometric, clinical, neuropsychological and biological measurements taken at various timepoints. Participants will be asked to complete a set of online questionnaires and data will be recorded anonymously. Biological samples will be collected at various time points.
Correlation between weight loss after treatment and clinical, neuropsychological and biological parameters.
The percentage of excessive weight loss after treatment will be correlated with * Clinical parameters (Binge Eating Scale and modified Yale Food Addiction Scale 2.0) * Neuropsychological parameter (Barratt Impulsivness Scale and Trail Making Test) * Biological parameters
Binge Eating Disorder.
Evaluation of eating disorders using the Binge Eating Scale (BES).
Food Addiction.
Evaluation of food addiction will be performed using modified Yale Food Addiction Scale 2.0.
Eating attitudes
Eating patterns and habits will be screened using the Eating Attitude Test 26
Cognitive flexibility.
Neuropsychological evaluation of cognitive flexibility will be performed with the Trail Making Test
Sociodemographic data
Number of children and marital status will be recorded
Medical history
Information concerning medical comorbidities will be collected from the patient medical record.
Childhood Trauma.
Assessment of adverse life events and trauma will used the Childhood Trauma Questionnaire - short form.
Click on the lead sponsor to view all of their trials.
