This is a prospective cohort study aiming to construct a prediction model for postoperative cognitive dysfunction (POCD) in elderly cardiac patients. We plan to enroll elderly patients aged ≥65 years undergoing cardiac surgery. Peripheral blood samples and functional magnetic resonance imaging (fMRI) data will be collected at baseline and key time points post-surgery. The primary objectives are to identify novel peripheral blood protein biomarkers for POCD, explore the correlation between fMRI characteristics and POCD, and establish a reliable early prediction model to improve perioperative management and reduce the incidence of POCD in elderly cardiac surgical patients.
Subjects aged ≥65 years, with no gender restriction. Patients meet the indications for cardiac surgery (cardiac surgery with cardiopulmonary bypass).
The investigator considers that the subject has conditions that may interfere with the study results.
This is a prospective cohort study enrolling elderly patients aged ≥65 years, regardless of gender, who are scheduled for elective cardiac surgery with cardiopulmonary bypass. Eligible subjects must have normal liver and renal function, no evidence of active infection during screening, and be able to cooperate with MMSE and MoCA cognitive assessments. Patients with conditions that may interfere with study results, active liver disease, preoperative severe cognitive impairment, uncontrolled comorbidities, organ transplantation history, demyelinating diseases, or participation in other clinical trials will be excluded. All participants provide written informed consent.
Cohort
Prospective
Not listed
Postoperative Cognitive Dysfunction Incidence in Elderly Cardiac Surgery Patients
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