About this trial
The primary objective of this study is to evaluate the effectiveness of inflammation index (pan-immune inflammation value, systemic immune inflammation index, and systemic inflammatory response index) values, calculated from routine pre- and post-operative blood test (hemogram) results of pregnant women undergoing cesarean section under spinal anesthesia, in predicting postdural puncture headache. Significant results will allow for the early identification of the population at risk of developing PPH and the implementation of preventive measures. The secondary objectives of the study are to evaluate the effects of factors such as demographic data (age, height, weight, and body mass index) obtained from patient records and the hospital information system, number of births, blood group, infant birth weight, smoking, previous history of postdural puncture headache (PPH), or headache in general, on the development of postdural puncture headache (PPH), to determine the frequency of PPH, and to identify the symptoms accompanying PPH.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
. Pregnant women who are of a cognitive level capable of giving informed consent
Pregnant women aged 18-45 who have undergone elective cesarean section
Term (37 weeks and above) pregnant women
Patients with an American Society of Anesthesiologists (ASA) physical status score of 2 (ASA II)
Disqualifiers
History of active infection or chronic inflammatory disease
History of steroid or immunomodulatory drug use
Presence of coagulopathy or hematological disorder
Presence of preeclampsia/HELLP syndrome
Trial population
Pregnant women undergoing cesarean section under spinal anesthesia
Trial design
Cohort
Prospective
Treatments tested in this trial
Not listed
Trial groups
Trial outcomes
Primary outcomes
The predictive role of inflammation indices for postdural puncture headache.
* The correlation between the preoperative basal panimmune inflammation value, systemic immune-inflammation index, and systemic inflammatory response index values and the development of PPH will be statistically evaluated. * Sensitivity and specificity evaluation will be performed for basal panimmune inflammation value, systemic immune-inflammation index, and systemic inflammatory response index values in those who develop PPH.
Secondary outcomes
PPH incidence
The incidence of PPH developing after postdural puncture will be investigated.
Sponsors and contacts
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