Predictive Accuracy of PLR and PNR in Detecting ETIC
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age12+
SponsorJubilee Mission Medical College and Research Institute
About this trial
Observational study to know what is the predictive accuracy of platelet-neutrophil ratio (PNR) and platelet-lymphocyte ratio (PLR) done in patients presenting to ED( emergency department)within 6 hours of trauma; in detecting early trauma induced coagulopathy during hospital admission
Eligibility criteria
This trial accepts healthy volunteersQualifiers
All patients with trauma AND
Presenting to ED within 6 hours of the event AND
The ED Physician sends coagulation profile
Disqualifiers
Treated with intravenous fluids, drugs, whole blood and blood products elsewhere
Patients admitted with a non-mechanical mechanism of injury, specifically drowning, hanging,or burns, as these mechanisms may result in a different biologic response than mechanical trauma
Patients on known medications affecting coagulation profile or hemogram
Patients with known chronic liver disease, chronic renal failure, malignancy, hematological disorders
Trial population
All patients with trauma AND Presenting to ED within 6 hrs of the event AND The ED Physician sends coagulation profile
Trial design
Design model
Case-only
Time perspective
Prospective
Treatments tested in this trial
Not listed
Trial groups
250 Participants
are grouped into 1 trial groupGroup A: Trauma patients with and without ETIC
Trial outcomes
Primary outcomes
1
1. Sensitivity, specificity, positive and negative predictive value
PLR and PNR ratio in predicting in-hospital transfusion requirement during index hospital admission.
Time frame
24 hoursSecondary outcomes
1
Compare the AUROC ( Area Under the Receiver Operating Characteristic Curve) of PLR and PNR ratio in predicting in-hospital transfusion requirement during index hospital admission
PLR and PNR ratio in predicting in-hospital 30 day mortality
Time frame
24 hours2
Compare the AUROC of PLR and PNR ratio in predicting prolonged ventilatory support (>21 days)
Prolonged ventilators support
Time frame
24 hours3
Compare the incidence of emergent surgery, renal replacement therapy amongst patients developing ETIC and those who do not during the duration of hospital stay or within 30 days (whichever is earlier)
Renal replacement therapy in patients with ETIC
Time frame
24hours4
Compare the length of hospital stay, total number of surgeries, total intensive care days in numbers amongst patients developing ETIC and those who do not during the duration of hospital stay or within 30 days (whichever is earlier)
length of hospital stay, total number of surgeries, total intensive care days in numbers amongst patients developing ETIC and those who do not during the duration of hospital stay or within 30 days
Time frame
24hoursSponsors and contacts
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Source ClinicalTrials.gov