Health TrialsbyHealthPanel

Predictive Role of sTREM in Endovascular Thrombectomy Outcomes

ConditionAcute Ischemic Stroke
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorThe Affiliated Hospital of Xuzhou Medical University

About this trial

Soluble triggering receptor expressed on myeloid cells (sTREM), which reflects microglia activation, has been reported closely associated with neuronal injury and neuroinflammation. This study is to investigatethe prognostic roles of sTREM (sTREM1 and sTREM2) in patients with ischemic stroke who underwent endovascular thrombectomy (EVT).

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Patients > 18 years old.

Patients with acute large vessel occlusion within 24 hours of onset who will receive endovascular treatment.

Disqualifiers

Impossibility of getting a blood sample.

Impossibility of performing the test (Invalid results).

Refusal to provide the informed consent by the patient/relative.

Trial population

There will be 200 patients with stroke who underwent EVT (Endovascular Therapy), 50 patients with non--EVT stroke and 50 non--stroke controls.

Trial design

Design model

Case-control

Time perspective

Prospective

Treatments tested in this trial

Not listed

Trial groups

300 Participants
are grouped into 3 trial groups
Group A: EVT-stroke group
Group B: non--EVT stroke group
Group C: non--stroke control group

Trial outcomes

Primary outcomes

1

Dynamic changes in plasma levels of sTREM-1 and sTREM-2 following Endovascular Therapy

Plasma levels of sTREM-1 and sTREM-2 will be quantified using the ELISA method.

Time frame
From baseline to immediately, 24 hours, 3 days, and 7 days after Endovascular Therapy

Secondary outcomes

1

favourable functional outcome, defined as modified Rankin Scale (mRS) 0-2

mRS ranges from 0-6, high score means poor outcome

Time frame
90 days
2

excellent functional outcome, defined as modified Rankin Scale (mRS) 0-1

mRS ranges from 0-6, high score means poor outcome

Time frame
30 days
3

early neurological improvement, defined as 4 or more decrease in National Institute of Health stroke scale (NIHSS)

NIHSS ranges from 0-22, with high score meaning severe neurological deficit.

Time frame
24 hours
4

Hemorrhagic transformation

Hemorrhagic transformation was diagnosed by Computed tomographic scans usually performed 24 to 72 hours after the procedure.Symptomatic intracranial hemorrhage was defined as neurologic deterioration (an increase of 4 or more points in the score on the NIHSS) and evidence of intracranial hemorrhage on imaging studies.

Time frame
72 hours

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

The Affiliated Hospital of Xuzhou Medical University

Lead sponsor

Source ClinicalTrials.gov
Apply now