Predictors of Cardiac Arrhythmia in Rheumatoid Arthritis Patients

ConditionRheumatoid Arthritis (RA)

Trial statusNot yet recruiting

Trial phaseNot listed

Trial typeObservational

Biological sexAll

Age18-65

SponsorAssiut University

About this trial

To evaluate QT dispersion, P-wave dispersion and Tp-e dispersion as predictors of cardiac arrhythmias in patients with rheumatoid arthritis and to assess their relationship with disease characteristics and inflammatory activity

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Patients diagnosed with rheumatoid arthritis according to the 2010 ACR/EULAR classification criteria

Age ≥18 years

Male and female patients

Disqualifiers

Presence of other autoimmune diseases

Thyroid disorders

Use of medications affecting cardiac conduction or repolarization such as amiodarone and other antiarrhythmic drugs

Electrolyte disturbances including hypocalcemia, hypokalemia and hypomagnesemia

Trial population

adult male and female participants aged ≥18 years, including patients with rheumatoid arthritis fulfilling the 2010 ACR/EULAR classification criteria and age- and sex matched healthy controls. Participants with other autoimmune diseases, thyroid disorders, cardiac diseases, electrolyte abnormalities (hypocalcemia, hypokalemia, or hypomagnesemia), or use of drugs known to affect cardiac rhythm such as amiodarone will be excluded

Trial design

Design model

Case-control

Time perspective

Prospective

Treatments tested in this trial

Not listed

Trial groups

120 Participants

are grouped into 2 trial groups

Group A: group 1 rheumatoid arthritis patients

Group B: group 2 healthy controls

Trial outcomes

Primary outcomes

QT dispersion, P-wave dispersion and Tp-e dispersion

to assess QT dispersion , P wave dispersion and Tp-e dispersion on 12 lead ECG and compare their values between rheumatoid arthritis patients and healthy controls and to evaluate their association with the risk of cardiac arrhythmia

Time frame

baseline

Secondary outcomes

Correlation between ECG parameters and disease activity assessed by DAS28

to evaluate the correlation between QT dispersion P wave dispersion Tp-e dispersion with rheumatoid arthritis disease activity assessed by DAS28

Time frame

at baseline

Locations

This trial has no locations.

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Assiut University

Lead sponsor

Source ClinicalTrials.gov

This trial is not recruiting at the moment. You can still explore other options: