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Predictors Of Outcome After Coronary Artery Bypass Graft Surgery Using Cardiopulmonary Bypass

ConditionsClinical OutcomesCardiac SurgeryCardio-pulmonary Bypass
Trial statusNot yet recruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18+
SponsorAlexandria University

About this trial

In cardiac operations, high values of blood lactate have been associated with bad outcomes if detected both during CPB and at the arrival in the intensive care unit (ICU) in adult patients. Many studies highlighted the potential role of hyperlactatemia on admission to the ICU as a marker for adverse outcome, and one study linked hyperlactatemia during CPB with postoperative morbidity and mortality. Evidence that both CENTRAL VENOUS SATURATION (ScVO2) and blood lactates during CPB are potential early predictors of morbidity and mortality in adult cardiac operations are still lacking.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Aged 18 years or above.

Operated with cardiopulmonary bypass.

Disqualifiers

Preoperative lactate level greater than 3 mmol/l.

Redo surgery.

If the patient will be reoperated during the study time.

Preoperative hemoglobin level less than 10 mg/dl.

Trial design

Design model

Parallel

Treatments tested in this trial

  • CORONARY BYPASS SURGERY USING CARDIOPULMONARY BYPASS

    Procedure/Surgery

    The study will be conducted on cardiac surgical patients who will undergo isolated elective CABG with nonpulsatile flow during cardiopulmonary bypass

  • cardiac surgical patients who will undergo isolated elective cardiopulmonary bypass

    Procedure/Surgery

    The study will be conducted on cardiac surgical patients who will undergo isolated elective CABG with pulsatile flow during cardiopulmonary bypass

Treatment groups

60 Participants
are divided into 2 treatment groups
Group A: Group (P): Pulsatile flow will be used during CPBExperimental treatment 1 intervention
Group B: Group NP: non-pulsatile perfusion.Active comparator 1 intervention

Trial outcomes

Primary outcomes

1

effects of pulsatile versus non-pulsatile perfusion methods in CABG surgeries on arterial lactate level.

Arterila Lactate values (mmol/L).

Time frame
24 hour
2

effects of pulsatile versus non-pulsatile perfusion methods in CABG surgeries on saturation of central venous blood.

saturation of central venous blood (percentage)

Time frame
24 hour

Secondary outcomes

1

The duration of mechanical ventilation (hours).

Time frame
24 hour
2

Length of ICU stay (days)

Time frame
24 hour
3

Occurrence of major morbidity

The occurrence of at least one in-hospital morbidity with or without in-hospital mortality. (Stroke, seizures, myocardial ischemia, low cardiac output state, post-perfusion syndrome, acute kidney injury, pancreatitis, acute hepatitis, and any other complication will be recorded

Time frame
72 hours

Other outcomes

Locations

This trial has no locations.

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Alexandria University

Lead sponsor

Source ClinicalTrials.gov

This trial is not recruiting at the moment. You can still explore other options: