This prospective observational cohort study aims to identify independent predictors of rapid chronic kidney disease (CKD) progression and determine its incidence among predialysis CKD patients. A total of 190 adult patients will be enrolled from the nephrology outpatient clinic and inpatient ward at Assiut University Hospitals and followed for 24 months. Rapid progression is defined as a sustained decline in eGFR \> 5 mL/min/1.73 m² per year according to KDIGO 2024 criteria. Clinical and laboratory parameters will be assessed at baseline and during follow-up to identify predictive factors
Age 18 years or older
Diagnosis of CKD according to KDIGO 2024 criteria
Predialysis status (not on maintenance dialysis)
Ability to provide written informed consent
Acute kidney injury
Current maintenance dialysis
Previous kidney transplantation
Active malignancy
Adult patients with predialysis chronic kidney disease (CKD) attending the Nephrology outpatient clinic and inpatient ward at Assiut University Hospitals.
Cohort
Prospective
Not listed
Incidence of rapid CKD progression
Proportion of participants who experience rapid CKD progression, defined as a sustained decline in eGFR greater than 5 mL/min/1.73 m² per year.
Independent predictors of rapid CKD progression
Clinical and laboratory variables independently associated with rapid CKD progression using multivariate logistic regression analysis.
Change in estimated glomerular filtration rate (eGFR)
Absolute change in eGFR (mL/min/1.73 m²) from baseline to follow-up visits.
Change in albuminuria
Change in urine albumin-to-creatinine ratio from baseline to follow-up visits.
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