The goal of this study is to learn more about the risk factors associated with left ventricular non-compaction (LVNC) and the predictors of adverse outcomes associated with LVNC. The main questions this study aims to answer are as follows.
* Are there any genetic mutations that impact the risk of LVNC patients developing ventricular arrhythmias? * Does LV myocardial strain increase risk stratification in the LVNC population with or without genetic mutations? * What are some of the determinants that cause LV dysfunction in LVNC? * What are other risk stratifiers (ex. premature ventricular contraction (PVC) burden on Holter, non-sustained ventricular tachycardia (NSVT) on stress test) that lead to an outcome of ICD implantation?
Participants will have their medical records accessed annually for a span of ten years, either prospectively or retrospectively depending on whether they are being actively followed by physicians at the Inherited Arrhythmia Clinic or not, to evaluate LVNC progression over time. This data will be stored in a large clinical registry with the London Heart Rhythm Program at the London Health Sciences Centre, University Hospital Campus.
Have a confirmed diagnosis of LVNC (between 2010-2020 for patients in the retrospective cohort only)
Be over 18 years of age
None
Patients in this study have a confirmed diagnosis of LVNC. Specifically, those in the prospective cohort are being actively followed up by physicians at the Inherited Arrhythmia Clinic whereas those in the retrospective cohort are no longer being actively followed up.
Case-only
Other
Not listed
Develop a large clinical registry linked with the Inherited Arrhythmia Clinic
The Inherited Arrhythmia Clinic is a subdivision of the London Heart Rhythm Program at University Hospital, London Health Sciences Centre. As such, data will not go offsite but will simply be stored in a local REDCap database.
Identification of genetic mutations linked to LVNC
Enrolled patient's will have their genetic test results thoroughly reviewed (if applicable) to better understand their involvement in the onset and progression of LVNC.
Identification of determinants that cause LV dysfunction
Enrolled patient's will have their medical charts accessed to identify factors contributing to LV dysfunction in patients with LVNC.
Identification of factors that lead to ICD implantation
Enrolled patient's will have their medical charts accessed to identify risk factors that lead to ICD implantation (if applicable) in patients with LVNC.
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