Pregnancy Outcomes After Breast Cancer in Young Women With Germline Pathogenic Variants in Genes Other Than BRCA
Trial statusNot yet recruiting
Trial phaseNot listed
Trial typeObservational
Biological sexFemale
Age18-40
SponsorJules Bordet Institute
About this trial
The present study aims to refine the understanding of the prognostic impact of pregnancy after breast cancer in young women harboring germline pathogenic variants in breast cancer susceptibility genes other than BRCA
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
Diagnosis of stage I-III invasive breast cancer between January 2000 and December 2025
Age at breast cancer diagnosis ≤40 years
Germline pathogenic variant in at least one of the following breast cancer susceptibility genes other than BRCA: TP53, PALB2, PTEN, CDH1, STK11, CHEK2, ATM, BARD1, RAD51C, or RAD51D
Disqualifiers
Known germline pathogenic variant in breast cancer susceptibility genes without a diagnosis of invasive breast cancer
Diagnosis of ovarian cancer or other malignancies without a prior history of invasive breast cancer
Diagnosis of invasive breast cancer with germline variants of uncertain significance in breast cancer susceptibility genes
De novo stage IV breast cancer
Trial population
Young women diagnosed at age 40 years or younger with stage I-III invasive breast cancer between January 2000 and December 2025 and harboring a germline pathogenic variant in a breast cancer susceptibility gene other than BRCA1/2, including TP53, PALB2, PTEN, CDH1, STK11, CHEK2, ATM, BARD1, RAD51C, and RAD51D.
Trial design
Design model
Cohort
Time perspective
Retrospective
Treatments tested in this trial
Not listed
Trial groups
2,200 Participants
are grouped into 2 trial groupsGroup A: Pregnant cohort
Group B: Non-pregnant cohort
Trial outcomes
Primary outcomes
1
Cumulative Incidence of Pregnancy After Breast Cancer Diagnosis
Time frame
Up to 20 years from breast cancer diagnosis2
Invasive Disease-Free Survival (iDFS)
Time frame
Up to 20 years from breast cancer diagnosisLocations
Sponsors and contacts
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Source ClinicalTrials.gov
This trial is not recruiting at the moment. You can still explore other options: