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Prehospital ECPR in Moravia Silesia Region

ConditionCardiac Arrest, Out-Of-Hospital
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18-70
SponsorUniversity Hospital Ostrava

About this trial

Cardiopulmonary resuscitation (CPR) for out-of-hospital cardiac arrest (OHCA) in specific cases could be improved by Extracorporeal membrane oxygenation (ECMO; ECPR). ECPR could be introduced in hospital after retrieval of an OHCA patient and also faster by implantation on scene. The aim is to verify the effectiveness of ECPR on scene in the Moravian-Silesian region.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Age ≥ 18 years

Observed collapse and presumption of cardiac cause of cardiac arrest

Estimated age up to 70 years

Baseline rhythm of ventricular fibrillation or pulseless electrical activity (PEA)

Disqualifiers

Children or adults with estimated weight below 40 kg

Known major comorbidities of the patient suggesting low rehabilitation potential (e.g. chronic obstructive pulmonary disease (COPD) IV, malignancy in tertiary phase)

Trial population

Patients after out-of-hospital cardiac arrest

Trial design

Design model

Case-only

Time perspective

Prospective

Treatments tested in this trial

  • Extracorporeal membrane oxygenation (ECMO)

    Procedure/Surgery

    In extracorporeal membrane oxygenation (ECMO), blood is pumped outside of the body to a heart-lung machine. The machine removes carbon dioxide and sends oxygen-rich blood back to the body. Blood flows from the right side of the heart to the heart-lung machine. It's then rewarmed and sent back to the body.

Treatment groups

100 Participants
are divided into 1 treatment group
Group A: Out-of-hospital cardiac arrest on ECMO1 intervention

Trial outcomes

Primary outcomes

1

Time from cardiac arrest (collapse) to implantation of ECMO

The time from cardiac arrest (collapse) to implantation of ECMO will be recorded and assessed

Time frame
up to 60 minutes
2

Hospital mortality

Hospital mortality will be assessed for the period of 3 weeks

Time frame
up to 3 weeks
3

Cerebral Performance Category (CPC) score

Cerebral Performance Category (CPC) score will be observed 30 days after cardiac arrest

Time frame
30 days
4

Neurological outcome (CPC score)

Neurological outcome will be assessed using the Cerebral Performance Category Scale (CPC) 6 months after cardiac arrest.

Time frame
6 months

Secondary outcomes

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

University Hospital Ostrava

Lead sponsor

Emergency Medical Services, Moravian-Silesian Region

Collaborator

Source ClinicalTrials.gov
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