The goal of this observational study is to evaluate the possibility to use prenatal ultrasonography for diagnosis and prognostic guidance in cases of suspected fetal thyroid changes in fetuses belonging to women with thyroid disease and women with low obstetric risk (i.e., pregnancy not complicated by maternal and/or fetal pathology) between 14 and 37 gestational weeks.
The main question it aims to answer is:
Is it possible to diagnose thyroid disease in fetuses early using measurable parameters of the fetal thyroid through ultrasonography?
Participants between 14 and 37 gestational weeks, who will be followed for the entire period of pregnancy, up to delivery, at the same enrolling center
Obtaining informed consent for participation in the study
Maternal age between 18 and 45 years (extremes included)
Participants with good understanding of the Italian language
Smoking participants
Patients with BMI>30
Absence of correct dating of pregnancy within the first trimester
Pathological conditions (e.g., malabsorptive or socioeconomic conditions that may interfere with fetal growth)
Patients from 14 to 37 weeks of pregnancy, with thyroid disease or at low obstetric risk who will undergo obstetric ultrasound at the outpatient clinics of the hospitals where they will deliver.
Cohort
Prospective
Description of the trend of major thyroid ultrasound biometric parameters
Diagnostic testUse of prenatal ultrasonography for diagnosis and prognostic guidance in suspected fetal thyroid changes.
Fetal thyroid volume = (π/6) × Longitudinal diameter × Antero-Posterior diameter × Transverse diameter (mm3)
Description of the trend of major thyroid ultrasound biometric parameters in fetuses belonging to women with thyroid disease and women at low obstetrical risk
Right and left thyroid lobe transverse diameter (mm)
Description of the trend of major thyroid ultrasound biometric parameters in fetuses belonging to women with thyroid disease and women at low obstetrical risk
Longitudinal diameter right and left thyroid lobe (mm)
Description of the trend of major thyroid ultrasound biometric parameters in fetuses belonging to women with thyroid disease and women at low obstetrical risk
Antero-posterior diameter right and left thyroid lobe (mm)
Description of the trend of major thyroid ultrasound biometric parameters in fetuses belonging to women with thyroid disease and women at low obstetrical risk
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