How to accurately and safely evaluate regional liver function before hepatectomy remains an important unsolved problem in the surgical management of hepatocellular carcinoma (HCC). We plan to develop a non-invasive, functional 3D-MRE-based method for preoperative regional hepatic functional reserve assessment, and to evaluate its ability to predict surgical risk and postoperative liver failure in patients with HCC undergoing hepatectomy.
Age 18-80 years
Pathologically or radiologically confirmed diagnosis of one of the following: hepatocellular carcinoma, intrahepatic cholangiocarcinoma, or liver metastasis (e.g., from colorectal cancer)
Scheduled to undergo curative hepatectomy
Child-Pugh class A or B liver function
Contraindication to MRI (e.g., non-MRI-compatible implants, severe claustrophobia)
Child-Pugh class C liver function
Prior history of liver resection or liver transplantation
Presence of extrahepatic metastasis