Preoperative Neutrophil-to-Lymphocyte Ratio and Early Postoperative Pain After Septorhinoplasty
Trial statusNot yet recruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18-65
SponsorIstinye University
About this trial
This prospective, observational study investigates the relationship between early oxygen exposure and oxidative stress in adult intensive care unit patients with sepsis or septic shock. Fraction of inspired oxygen (FiO₂) administered during the first 24 hours of ICU admission will be recorded and analyzed in relation to changes in the uric acid/albumin ratio (UAR), a biomarker reflecting oxidative burden and inflammation. Serum uric acid and albumin levels will be measured at baseline and at 24 hours, and the percentage change in UAR will be calculated. Secondary analyses will examine associations between UAR changes, oxygenation indices, and 28-day mortality. The study aims to determine whether higher FiO₂ exposure is associated with increased oxidative stress and to evaluate the potential role of UAR as a clinically accessible marker of oxygen-related oxidative injury in septic ICU patients.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
Adult patients aged 18-65 years
Patients undergoing elective septorhinoplasty
Surgery performed under general anesthesia
Complete recording of early postoperative VAS pain scores, Aldrete scores, NUDES scores, and vital signs in the Post-Anesthesia Care Unit (PACU)
Disqualifiers
Patients undergoing emergency surgery
Septorhinoplasty combined with additional major surgical procedures (e.g., advanced ENT or maxillofacial surgery)
Presence of known hematological disease, active infection, immunosuppressive therapy, or advanced liver or renal failure
Chronic opioid use or regular analgesic medication use in the preoperative period
Trial population
The study population consists of adult patients aged 18-65 years who undergo elective septorhinoplasty under general anesthesia. All participants are managed according to standard clinical practice and are admitted to the Post-Anesthesia Care Unit (PACU) postoperatively, where early pain assessments and routine clinical monitoring are performed. Eligible patients have a complete preoperative hemogram obtained within 30 days prior to surgery and comprehensive postoperative records, including pain scores and vital signs. Patients with conditions or treatments that could significantly affect inflammatory markers or pain perception are excluded to ensure a homogeneous study population
Trial design
Design model
Cohort
Time perspective
Prospective
Treatments tested in this trial
Observational Study
Other interventionNot applicable. This is a prospective observational study. No intervention or alteration to standard treatment protocols will be performed. Clinical and laboratory data obtained during routine care, including preoperative hemogram parameters and early postoperative pain scores, will be recorded and analyzed without influencing patient management.
Treatment groups
No treatment groups listed
Trial outcomes
Primary outcomes
1
Early Postoperative Pain Severity
early postoperative pain severity, as measured using the Visual Analog Scale (VAS). 0: no pain, 10 worst pain
Time frame
Within the first 60 minutes after admission to the Post-Anesthesia Care Unit (PACU).Locations
Sponsors and contacts
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Source ClinicalTrials.gov
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