Preoperative Serum FGF19 in the Prognosis of Biliary Atresia
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
AgeNot listed
SponsorChildren's Hospital of Fudan University
About this trial
To investigate the role of preoperative serum FGF19 level in the prognosis of biliary atresia.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
Samples diagnosed as biliary atresia in Children's Hospital of Fudan University
Samples with one-year follow-up records after surgery
Samples with a record of serum total bilirubin levels three months after surgery
Samples with preoperative serum left（volume > 500ul)
Disqualifiers
None
Trial population
The study enrolled patients meeting following conditions. * Patients diagnosed as biliary atresia in Children's Hospital of Fudan University * Patients with at least one-year follow-up records after surgery * Patients with a record of serum total bilirubin levels three months after surgery * Patients with preoperative serum left（volume \> 500ul)
Trial design
Design model
Case-control
Time perspective
Retrospective
Treatments tested in this trial
Not listed
Trial groups
200 Participants
are grouped into 1 trial groupGroup A: Good prognosis + Poor prognosis
Trial outcomes
Primary outcomes
1
Serum total bilirubin level (umol/l)
The difference of serum total bilirubin level will be measured with ELISA( Enzyme Linked ImmunoSorbent Assay) three months after surgery
Time frame
Three months after surgery2
Native liver survival (%)
The difference of native liver survival will be measured according to the follow-up statue one year after surgery
Time frame
One year after surgerySponsors and contacts
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Source ClinicalTrials.gov