Preoperative Ultra-hypofractionated Radiotherapy Followed by Surgery for Retroperitoneal Sarcoma (FUSION-01)

ConditionsSoft Tissue Sarcoma Retroperitoneal Sarcoma Radiotherapy Side Effect Ultra-hypofractionated Radiotherapy Stereotactic Ablative Radiotherapy

Trial statusRecruiting

Trial phaseNot applicable

Trial typeInterventional

Biological sexAll

Age18+

SponsorCancer Institute and Hospital, Chinese Academy of Medical Sciences

About this trial

To investigate the feasibility and peri-operative complications of preoperative hypo-fractionated radiotherapy followed by surgery for retroperitoneal sarcoma

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Primary soft tissue sarcoma of retroperitoneal or infra-peritoneal spaces of pelvis

Sarcoma not originated from bone structure, abdominal or gynecological viscera

All disease can be included safely within one radiotherapy field

Absence of extension through the sciatic notch or across the diaphragm

Disqualifiers

metastatic disease

Tumor was previously treated by radiotherapy

Involvement of liver, pancreatic head or duodenum

Trial design

Design model

Single group

Treatments tested in this trial

ultra-hypofractionated radiotherapy
Radiation
stereotactic ablative radiotherapy with 25 to 50Gy in five fractions given preoperatively

Treatment groups

50 Participants

are divided into 1 treatment group

Group A: Ultra-hypofractionated radiotherapyExperimental treatment 1 intervention

Trial outcomes

Primary outcomes

Peri-operative complications

The proportion of patients who suffer from

Time frame

From surgery date up to 7 days later

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Cancer Institute and Hospital, Chinese Academy of Medical Sciences

Lead sponsor

Source ClinicalTrials.gov

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