Prevalence and Characteristics of Restless Leg Syndrome in Thai Patients With Parkinson's Disease
ConditionRestless Legs Syndrome
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18-80
SponsorSiriraj Hospital
About this trial
Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized by pathologic intraneuronal alpha-synuclein-positive Lewy bodies and neuronal cell loss. The cardinal clinical symptoms and signs of PD are bradykinesia, rigidity, tremor, postural instability, and freezing attacks. The prevalence of PD increases with age, affecting 1-2% of the population over the age of 65 years, and 3% of those over 85 years.
Restless legs syndrome (RLS) represents disturbing symptoms in lower limbs that lead to the urge to move, occurring in rest periods. Movements can partially or completely relieve these abnormal feelings. In 2014, the International RLS Study Group (IRLSSG) established five mandatory criteria for the diagnosis of RLS. Several studies supported that RLS and PD may share pathophysiological mechanisms.
Eligibility criteria
This trial accepts healthy volunteersQualifiers
Patients with Parkinson's disease aged from 18 to 80 years who met the United Kingdom Parkinson's Disease Society (UKPDS) Brain Bank Diagnostic criteria.
Disqualifiers
Patients with atypical or secondary parkinsonism.
Patients with Mini-mental status exam (MMSE) less than 24 of 30.
Patients with secondary causes of restless leg syndrome including end-stage renal disease, iron deficiency anemia and pregnancy.
Trial population
Patients with Parkinson's disease aged from 18 to 80 years who met the UK Parkinson's Disease Society Brain Bank Diagnostic Criteria. The patients must regularly visit the movement disorders clinic at least 2 times per year.
Trial design
Design model
Cohort
Time perspective
Prospective
Treatments tested in this trial
Screening for symptoms of restless leg syndrome
Other interventionThe patients will be screened for restless leg syndrome by clinical questioning.
Treatment groups
310 Participants
are divided into 1 treatment groupGroup A: Patients with parkinson's disease1 intervention
Trial outcomes
Primary outcomes
1
The prevalence of restless leg syndrome in patients with Parkinson's disease
Time frame
At the time of recruitmentSecondary outcomes
1
Clinical characteristics of Parkinson's disease patients with restless leg syndrome
Time frame
At the time of recruitmentSponsors and contacts
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Source ClinicalTrials.gov