This study aims to investigate the prevalence of adrenal insufficiency in rheumatoid arthritis (RA) patients receiving low-dose corticosteroid therapy and to identify the factors influencing adrenal insufficiency. To this end, the researchers plan to conduct a study comparing the prevalence of adrenal insufficiency and associated factors among RA patients-who are currently receiving low-dose corticosteroid therapy during outpatient follow-up and have consented to participate-by categorizing them into three groups based on the duration of treatment: short (3 weeks-3 months), medium (3-12 months), and long (\>12 months).
Participants diagnosed with rheumatoid arthritis according to the 2010 ACR/EULAR criteria.
Participants who have been undergoing corticosteroid treatment for at least 3 weeks.
Participants in remission or with low disease activity (DAS28-CRP ≤3.2).
Patients with primary adrenal insufficiency.
Participants who have received pulse steroid therapy within the last 6 months.
Pregnancy and lactation.
Hypopituitarism
The study population will be selected from RA patients followed at the Rheumatology Clinic of Bursa Yuksek Ihtisas Training and Research Hospital.
Case-only
Cross-sectional
ACTH stimulation test
Diagnostic testACTH stimulation test with 250 micrograms tetracosactide acetate if plasma cortisole is below 10 mcg/dl
Cortisol
Diagnostic testmorning fasting plasma cortisol
prevalence of adrenal insufficiency
The assessment of adrenal insufficiency is conducted in two stages: the morning cortisol level is measured in the first stage, and the ACTH stimulation test is administered to the relevant participants in the second stage.
DAS-28
Disease activity score for rheumatoid arthritis
HAQ
Health Assessment Questionnaires
RAPİD-3
Routine Assessment of Patient Index Data 3
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Bursa Yuksek Ihtisas Training and Research Hospital
Lead sponsor
Saglik Bilimleri Universitesi
Sponsor institution
