Pre-eclampsia is a hypertensive disorder of pregnancy that can lead to significant health complications for both the mother and the fetus. Asymptomatic bacteriuria (ASB) occurs when significant amounts of bacteria are present in the urinary tract without causing symptoms such as burning, pain, or fever. Research suggests that persistent, asymptomatic bacterial growth can stimulate inflammatory responses and endothelial dysfunction, which may contribute to or worsen pre-eclampsia. However, local data regarding how frequently this condition occurs among pre-eclamptic women in Assiut remains limited.
The primary purpose of this cross-sectional study is to determine the prevalence of asymptomatic bacteriuria among pregnant women diagnosed with pre-eclampsia admitted to or attending the Department of Obstetrics and Gynecology at Women's Health Hospital, Assiut University. The study also aims to identify the specific bacterial species responsible for these infections, assess their antibiotic susceptibility profiles, and evaluate potential sociodemographic and clinical risk factors.
Enrolled participants will be asked to complete a structured interview questionnaire regarding their medical history, obstetric history, and sociodemographic details. Each participant will provide a single clean-catch midstream urine sample for quantitative urine culture and microbiological analysis. Positive culture results will be communicated to the treating clinical team to guide targeted antibiotic management.
Pregnant women aged 18 to 45 years
Gestational age ≥ 20 weeks
Singleton or multiple pregnancy
Clinically diagnosed with pre-eclampsia
Presence of clinical symptoms of a urinary tract infection
History of antimicrobial/antibiotic therapy within the preceding 2 weeks prior to recruitment
Documented pre-existing chronic kidney disease
Known congenital or acquired structural urinary tract abnormalities
Pregnant women diagnosed with pre-eclampsia attending the inpatient wards and outpatient clinics of the Department of Obstetrics and Gynecology at Women's Health Hospital, Assiut University Hospitals, who are at 20 or more weeks of gestation and present without clinical symptoms of a urinary tract infection.
Cohort
Cross-sectional
Not listed
Percentage of Participants With Asymptomatic Bacteriuria
Asymptomatic bacteriuria is defined as significant bacterial growth (≥10\^5 CFU/mL of a single bacterial pathogen) isolated from a clean-catch midstream urine culture in the absence of urinary tract infection symptoms. It will be calculated as the number of pre-eclamptic pregnant women with confirmed bacteriuria divided by the total number of enrolled participants, expressed as a percentage.
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