Health TrialsbyHealthPanel

Prevalence of Ethnic Neutropenia and Duffy Null Phenotype in Neonates

ConditionNeutropenia (Low White Blood Cell Count)
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age1-1
SponsorKaplan Medical Center

About this trial

This is a prospective observational study designed to assess the prevalence of the Duffy null phenotype (associated with ethnic neutropenia) in neonates born at Kaplan Medical Center. Blood samples will be collected from umbilical cords (non-invasively) to evaluate Duffy antigen expression. Data on ethnicity, perinatal factors, and routine blood counts at 9-12 months (when available) will also be collected to correlate phenotype with absolute neutrophil count (ANC).

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Neonates born at Kaplan Medical Center between 1.9.2024 and 31.12.2025

Parental informed consent obtained

Umbilical cord blood available for routine testing

Disqualifiers

None

Trial population

Neonates born at Kaplan Medical Center

Trial design

Design model

Cohort

Time perspective

Prospective

Treatments tested in this trial

  • Cord blood

    Diagnostic test

    Cord blood samples will be collected during routine G6PD testing. An additional 3 mL will be obtained non-invasively from the umbilical cord to determine the expression of Duffy antigens using serologic gel testing.

Treatment groups

1,000 Participants
are divided into 1 treatment group
Group A: Neonatal birth cohort1 intervention

Trial outcomes

Primary outcomes

1

Prevalence of Duffy null phenotype in neonates

Percentage of neonates born with the Duffy null phenotype (Fya-/Fyb-) as determined by serologic gel-based testing.

Time frame
At birth (umbilical cord sample)

Secondary outcomes

1

Prevalence of neutropenia in infants with Duffy null phenotype

Percentage of Duffy null infants with ANC \<1000/µL based on routine CBC performed at at 9-12 months

Time frame
9-12 months
2

Association between parental ethnicity and Duffy null phenotype

Distribution of Duffy null phenotype stratified by self-reported parental origin.

Time frame
At birth

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Kaplan Medical Center

Lead sponsor

Source ClinicalTrials.gov
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