Prevention and Rehabilitation of Stroke in Uganda
ConditionStroke
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age13+
SponsorKarolinska Institutet
About this trial
Stroke is increasing in low-income countries in Africa, and knowledge is lacking on risk factors and how to prevent stroke as well as how to best use the resources for rehabilitation after stroke which are very limited. Knowledge generation within this area is therefore urgently needed. This collaboration between the research group HELD (Health and Everyday Life among people with neurological Disorders), Karolinska Institutet (KI) and the research surveillant site Africa Medical and Behavioral Sciences Organization (AMBSO) population health surveillance (PHS), will create substantial research opportunities to develop and improve prevention and rehabilitation for stroke, which is in line with the sustainable development goals to reduce the prevalence and mortality rates due to NCDs. AMBSO is collecting data from 17 000 households on many potential risk factors for stroke. Questions about stroke primary and secondary prevention of stroke and impact of stroke or need of rehabilitation could be added to the existing questionnaires such as the validated Ugandan version of the Stroke Impact Scale. This is intended to fulfill the aim of the network which is to increase the knowledge of occurrence and consequences of NCDs with a specific focus on stroke, which will be valuable for the development of preventive healthcare policy documents and guidelines for appropriate prevention strategies and rehabilitation interventions.
Research questions in relation to NCDs with focus on stroke prevention and rehabilitation:
* How many cases (prevalence) are reported in the targeted study sites and what is the mortality rate (incidence) that can specifically relate to stroke? * How does stroke and other NCDs affect and impact the quality of life for persons living in Uganda? * Which factors impact the recovery process after stroke? * What sort of rehabilitation is needed in the study areas for persons affected by stroke? In addition, risk factors of stroke such as diabetes and hypertension will be mapped.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
Stroke
Risk factors for stroke: hypertension, diabetes, HIV, malaria, physical inactivity, obesity
Disqualifiers
Not having had stroke and/or having no risk factor for stroke
Trial population
Community sample from Wasiko and Hoima in Uganda
Trial design
Design model
Cohort
Time perspective
Prospective
Treatments tested in this trial
Not listed
Trial groups
50 Participants
are grouped into 1 trial groupGroup A: People with stroke
Trial outcomes
Primary outcomes
1
Stroke Impact Scale-16
Questionnaire comprising 16 statements concerning perceived impact of stroke. Each item is rated on a scale from 0 (high impact) to 5 (no impact).
Time frame
At one assessment point during 2023-20242
Stroke Impact Scale, perceived recovery
Perceived recovery after stroke is rated on a visual analogue scale ranging from 0 (no recovery) to 100 (full recovery).
Time frame
At one assessment point during 2023-2024Secondary outcomes
1
Life Satisfaction Checklist (LISat-11)
Questionnaire that assesses life satisfaction with one global item "Life as a whole", and 9 domain-specific items. Answering alternatives range from 1 (very dissatisfied) to 6 (very satisfied)
Time frame
At one assessment point during 2023-20242
Patient Health Questionnaire-9
Questionnaire with nine items that inquire about the frequency of depressed mood and anhedonia over the past two weeks. Score ranges from 0 (not at all) to 6 (nearly every day) where higher scores indicate higher frequency of depressed mood
Time frame
At one assessment point during 2023-20243
Generalized Anxiety Disorder Assessment-7
A questionnaire assessing generalized anxiety disorder. The GAD-7 score is calculated by assigning scores of 0, 1, 2, and 3, to the response categories of 'not at all', 'several days', 'more than half the days', and 'nearly every day', respectively, and adding together the scores for the seven questions.
Time frame
At one assessment point during 2023-20244
Health Literacy Questionnaire
Questionnaire that assesses health literacy. The Health Literacy Questionnaire contains 44 items, which are divided into nine areas of health literacy. The first five scales are scored on a 4-point Likert scale (ranging from strongly disagree to disagree, agree, and strongly agree), building part I. The other four scales, representing part II, are scored on a 5-point Likert scale where respondents are asked to rate the level of difficulty in undertaking a task (ranging from cannot do, always difficult, usually difficult, sometime difficult, usually easy, and always easy). Higher scores indicate better health literacy. In total six selected questions from part I and part II are used.
Time frame
At one assessment point during 2023-2024Sponsors and contacts
Click on the lead sponsor to view all of their trials.
Karolinska Institutet
Lead sponsor
The Swedish Research Council
Collaborator
Source ClinicalTrials.gov