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Prevention of Emergence Agitation in Rhinoplasty With Subanesthetic Propofol and Single-Dose Dexmedetomidine: A Prospective Double-Blind Clinical Study

ConditionEmergence Agitation
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-65
SponsorYuzuncu Yil University

About this trial

To compare of prevention of emergence agitation in rhinoplasty with subanesthetic propofol and single dose dexmedetomidine

Eligibility criteria

This trial accepts healthy volunteers

Qualifiers

Patients scheduled for rhinoplasty

Between 18-65 years

ASA I-II group

Disqualifiers

Those who are outside the age range of 18-65

Those who are ASA III and above

Those with renal,hepatic, cardiac and respiratory diseases

Those with a known allergy to the medication to be used

Trial design

Design model

Parallel

Treatments tested in this trial

  • Dexmedetomidine

    Drug

    In rhinoplasty, 10 minute infusion of 0,5 mcg/kg dexmedetomidine will be administered after nasal packing

  • Propofol

    Drug

    In rhinoplasty, 0,5 mg/kg propofol IV bolus will be administered after nasal packing

Treatment groups

80 Participants
are divided into 2 treatment groups
Group A: Dexmedetomidine (Group-D)Active comparator 1 intervention
Group B: Propofol (Group-P)Experimental treatment 1 intervention

Trial outcomes

Primary outcomes

1

Agitation status

The effect on prevention of emergence agitation of propofol and dexmedetomidine will be evaluated by an anaesthetist with the Richmond Agitation Sedation Scale (RASS) at 1 minute after extubation

Time frame
1. minute after extubation

Secondary outcomes

1

Heart rate

Heart rate will be measured pre-induction of anesthesia, post-induction of anesthesia, 5th, 10th, 15th minutes after intubation, during extubation, 1st, 5th, 10th, 15th minutes after extubation

Time frame
perioperatively defined times
2

Blood Pressure

Systolic blood pressure, diastolic blood preesuure, mean arterial pressure will be measured pre-induction of anesthesia, post-induction of anesthesia, 1st, 5th, 10th, 15th minutes after intubation, during extubation, 5th, 10th, 15th minutes after extubation

Time frame
perioperatively defined times
3

oxygen saturation

Oxygen saturation will be measured pre-induction of anesthesia, post-induction of anesthesia, 5th, 10th, 15th minutes after intubation, during extubation, 1st, 5th, 10th, 15th minutes after extubation

Time frame
perioperatively defined times

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Yuzuncu Yil University

Lead sponsor

Source ClinicalTrials.gov
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