About this trial
In the PRINCE study we recruit healthy but also diseased pregnant women into a cohort study, followed by the assessment of children´s health and immunity at birth and during the first 10 years of life. This unique cohort allows for testing the impact of prenatal challenges on children´s health.
Eligibility criteria
This trial accepts healthy volunteersQualifiers
Pregnant women
>18 years of age
able to understand and sign the papers of consent
singleton pregnancy
Disqualifiers
<18 years of age
unable to give consent
multiple pregnancy
nicotine abuse
Trial population
The PRINCE cohort includes healthy or diseased pregnant women aged 18-45 years. Women gaining knowledge of the study from their gynecologist, in the clinic or from other participants.
Trial design
Cohort
Prospective
Treatments tested in this trial
Not listed
Trial groups
Trial outcomes
Primary outcomes
Types of allergic diseases in childhood
The different types of allergic diseases are assessed by a yearly questionnaire, a pediatric examination and lung function testing of the child aged 5 and 9 1/2 years, as well as analysing blood samples of the child aged 5 and 9 1/2 years. Main allergies we measure are inhalation allergens and infant food.
Secondary outcomes
influences during pregnancy that potentially affect children´s health
assessed by maternal examination during pregnancy including ultrasound in every trimester
influences during pregnancy that potentially affect children´s health
assessed by questionaire every trimester with questions about nutrition, infections, medication, stress (...)
influences during pregnancy that potentially affect children´s health
assessed by analysing blood samples of the mother in every trimester and analysing cord blood
Sponsors and contacts
Click on the lead sponsor to view all of their trials.