PRINCE Study - Cohort Study of Healthy Pregnant Women Followed by the Assessment of Children´s Health and Immunity

Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexFemale
Age18-50
SponsorUniversitätsklinikum Hamburg-Eppendorf

About this trial

In the PRINCE study we recruit healthy but also diseased pregnant women into a cohort study, followed by the assessment of children´s health and immunity at birth and during the first 10 years of life. This unique cohort allows for testing the impact of prenatal challenges on children´s health.

Eligibility criteria

This trial accepts healthy volunteers

Qualifiers

Pregnant women

>18 years of age

able to understand and sign the papers of consent

singleton pregnancy

Disqualifiers

<18 years of age

unable to give consent

multiple pregnancy

nicotine abuse

Trial population

The PRINCE cohort includes healthy or diseased pregnant women aged 18-45 years. Women gaining knowledge of the study from their gynecologist, in the clinic or from other participants.

Trial design

Design model

Cohort

Time perspective

Prospective

Treatments tested in this trial

Not listed

Trial groups

No trial groups listed

Trial outcomes

Primary outcomes

1

Types of allergic diseases in childhood

The different types of allergic diseases are assessed by a yearly questionnaire, a pediatric examination and lung function testing of the child aged 5 and 9 1/2 years, as well as analysing blood samples of the child aged 5 and 9 1/2 years. Main allergies we measure are inhalation allergens and infant food.

Time frame
10 years follow up

Secondary outcomes

1

influences during pregnancy that potentially affect children´s health

assessed by maternal examination during pregnancy including ultrasound in every trimester

Time frame
10 years follow up
2

influences during pregnancy that potentially affect children´s health

assessed by questionaire every trimester with questions about nutrition, infections, medication, stress (...)

Time frame
10 years follow up
3

influences during pregnancy that potentially affect children´s health

assessed by analysing blood samples of the mother in every trimester and analysing cord blood

Time frame
10 years follow up

Other outcomes

Sponsors and contacts

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