This study is a series of descriptive-analytic studies on genomic variants in the facial skin of patients with AV at the Dermatology and Venereology Polyclinic by determining the genetic profile by GWAS examination in AVB and analysing the genetic profile in AVB against differences in geographical location. The research design used was a cross-sectional design.
Males or females with AVB aged 17-21 years
Both parents of complete subjects with or without a history of acne vulgaris aged up to 60 years
Patients and parents are willing to participate in the study and sign informed consent.
Patients who have other inflammatory or infectious diseases especially on the face
Have genetic diseases or disorders
Diagnosed with primary or secondary immunodeficiency diseases
Using oral or systemic antibiotic, anti-inflammatory, retinoid or hormone therapy in the past month.
Parallel
GWAS
GeneticIn GWAS studies, data are collected to determine common variants in a number of individuals, either with or without a common trait (for example,. disease) across the genome, using genome wide SNP arrays.
Severity of acne vulgaris
Physical examination: identify the number of blackheads, papules, pustules and cysts. Degree of severity:(1)Mild =Comedo\<20, or inflammatory lesion\<15, or total lesion\<30(2)Moderate = Comedo 20-100, or inflammatory lesion15-50, or total lesion 30-125(3)Severe =cyst\>5, or Comedo\>100, or inflammatory lesion\>50, or total lesion\>125.
Population structure
Gene testing of blood sample Genetic Inflation Factor (GIF) \>1.1 or \<1.1 Principal Component Analysis (PCA)
Genomic Profile
Blood sample examination, processed using GWAS Mutations (SNPs)(1)Present(2)Absent
Linkage disequilibirium (LD)
Gene testing of blood samples Coefficient 0-1
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Dr.dr.Irma Bernadette, SpKK (K)
Lead sponsor
Indonesia University
Sponsor institution
Indonesia Medical Education and Research Institute
Collaborator
