Prognosis of small vessel disease (SVD) depends on the underlying type of SVD and index manifestation.
The aim of this prospective, observational cohort study is to determine the risk of different outcome events among patients with SVD according to the type of index presentation.
Hypertensive deep perforator arteriolopathy (DPA), clinically symptomatic with either ICH, ischaemic stroke, cognitive impairment or severe radiological manifestation (Fazekas ≥II)
Cerebral amyloid angiopathy (CAA according to modified Boston or Edinburgh criteria), clinically symptomatic with either ICH (including cSAH), amyloid spells, cognitive impairment or severe radiological manifestation (CMB≥2)
Other SVD (i.e. CADASIL or other sporadic or genetic SVD)
Life expectancy of <6 months due to not-SVD related causes (i.e. cancer)
Patient is unlikely to attend follow-up visits
This is a prospectively recruited cohort of patients treated with cerebral small vessel disease at Inselspital Bern University Hospital. Patients are recruited at the emergency department, neurology in-patient ward, Stroke Unit, IMC, ICU and outpatient clinics.
Cohort
Prospective
Not listed
Intracerebral haemorrhage (ICH)
Non-traumatic, intracerebral haemorrhage (ICH, including convexity subarachnoid haemorrhage)
Ischaemic stroke
Defined by CT and/or MRI
Cardio-vascular death
According to the treating physician
Other intracranial bleeding
Subdural haematoma, subarachnoid haemorrhage
Other (transient) neurological attacks
Including transient ischaemic attack (TIA), transient neurological attack (TNA), amyloid spells, (focal) seizures
Cognitive impairment
Montreal Cognitive Assessment (MoCA, range 0-30 points) \< 26 points (corresponding to impaired cognitive function) and/or new impairment in activities of daily living as defined by the treating physician.
New-onset of extracranial vascular disease
As judged by the treating physician
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