Prognostic Impacts of Lipid Profile and BMI in Adult AML
Trial statusNot yet recruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorAssiut University
About this trial
The goal of this observational study is to evaluate the changes in lipid profile parameters (total cholesterol, triglycerides, HDL-C, and LDL-C) in adult AML patients before and after intensive induction chemotherapy. The main questions it aims to answer are:
* Are there correlations between metabolic changes (in lipid profile and BMI) and treatment outcomes, including remission status and incidence of chemotherapy-related complications? * Can the baseline lipid profile and BMI serve as prognostic markers for response to induction chemotherapy.?
Participants will be observed before and after induction chemotherapy regarding their lipid profile, and BMI, observing any correlations between the different results with any complications, and with remission status.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
Adult patients (≥18yearsold) newly diagnosed with AML.
Patients eligible for intensive induction chemotherapy.
Patients who have given informed consent to participate in the study.
Disqualifiers
Patients with secondary or relapsed AML.
Patients currently using lipid-lowering medications (e.g., statins).
Patients with known endocrine or metabolic disorders affecting BMI or lipid profile (e.g., uncontrolled diabetes, hypothyroidism, Cushing's syndrome).
Pregnant or lactating women.
Trial population
Adult patients(≥18yearsold) newly diagnosed with AML.
Trial design
Design model
Cohort
Time perspective
Prospective
Treatments tested in this trial
Not listed
Trial groups
No trial groups listed
Trial outcomes
Primary outcomes
1
Changes in lipid profile
Observing changes of lipid profile (total cholesterol, triglycerides, HDL-C, LDL-C) measured at baseline and after completion of induction therapy
Time frame
Pre-induction to post-induction (day 28-35).2
Changes in Body Mass Index
Observing changes of Body Mass Index (measured as weight in kilograms divided by squared height in meters) measured at baseline and after completion of induction therapy
Time frame
Pre-induction to post-induction (day 28-35)Secondary outcomes
1
Association of lipid profile changes with treatment response
Observing association of lipid profile changes with treatment response (complete remission, partial response, failure), occurrence of treatment-related complications (e.g., infections, tumor lysis syndrome), and duration of hospitalization.
Time frame
Pre-induction to post-induction (day 28-35).2
Association of Body Mass Index changes with treatment response
Observing association of Body Mass Index (measures as weight in kilograms divided by squared height in meters) changes with treatment response (complete remission, partial response, failure), occurrence of treatment-related complications (e.g., infections, tumor lysis syndrome), and duration of hospitalization.
Time frame
Pre-induction to post-induction (day 28-35)Sponsors and contacts
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Source ClinicalTrials.gov
This trial is not recruiting at the moment. You can still explore other options: