* To compare DHODH protein expression in HGSC tissues from patients undergoing Primary Debulking Surgery (PDS - Chemo-naive) versus Interval Debulking Surgery (IDS - Post-NACT). * To evaluate the association between DHODH expression and the degree of chemotherapy response (using the Chemotherapy Response Score - CRS for NACT cases). * To determine the prognostic value of DHODH expression in predicting Platinum-Free Interval (PFI) ,Progression -Free Survival (PFS) and Overall Survival (OS) across both groups.
Histologically confirmed high-grade serous ovarian carcinoma
Availability of adequate FFPE tumor tissue
Known treatment modality (PDS or IDS)
Available clinical follow-up including platinum-free interval and survival data
Non-serous histological subtypes
Low-grade serous carcinoma
Inadequate tissue for immunohistochemistry
Missing clinical or follow-up data