Progressive Heat Exposure and Physiological Strain

Trial statusNot yet recruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexMale
Age45-65
SponsorUniversity of Ottawa

About this trial

Occupational heat-stress guidelines are commonly based on the level of environmental heat exposure and are largely derived from studies conducted under constant environmental conditions. However, outdoor workers are typically exposed to dynamic conditions, with environmental heat often increasing progressively from morning to afternoon. Consequently, workers may experience substantially different patterns of heat exposure across the workday even when average daily heat exposure is equivalent. It remains unclear whether the temporal pattern of heat exposure influences the amount of work that can be performed or the physiological strain experienced during a workday. Understanding these responses is important for determining whether occupational heat-stress guidelines developed under constant laboratory conditions adequately protect workers exposed to progressively changing environmental conditions.

The primary objective of this study is to determine whether the temporal pattern of heat exposure influences work performed and physiological heat strain during a simulated occupational workday in healthy middle-aged and older men. Participants will complete two 9-hour simulated workdays consisting of a 4-hour morning work period, a 1-hour lunch break, and a 4-hour afternoon work period. During one trial, wet-bulb globe temperature (WBGT) will remain constant at 28°C throughout the workday, whereas during the other trial, WBGT will progressively increase from morning to afternoon to simulate the changing environmental conditions of a typical hot summer workday. Both trials will have the same mean daily WBGT of 28°C. Participants will perform moderate-intensity treadmill exercise, and measures including total work performed, core temperature, heart rate, and time to the initial stay-time threshold will be assessed to determine whether constant and progressively increasing heat exposures produce different physiological and work-performance responses across the workday.

Eligibility criteria

This trial accepts healthy volunteers

Qualifiers

Are male.

Do not smoke or have been smoke free for at least 5 years.

English or French speaking.

Ability to provide informed consent.

Disqualifiers

Are regularly exposed to hot environments (e.g., occupational heat exposure)

Experience claustrophobia or discomfort in enclosed environments

Episode(s) of severe hypoglycemia (requiring the assistance of another person) within the previous year, or inability to sense hypoglycemia (hypoglycemia unawareness).

Serious complications related to diabetes (gastroparesis, renal disease, uncontrolled hypertension, severe autonomic neuropathy).

Trial design

Design model

Crossover

Treatments tested in this trial

  • Constant Heat Exposure

    Other intervention

    Participants complete a simulated occupational workday under constant environmental conditions, with WBGT maintained at 28°C throughout the morning and afternoon work periods.

  • Progressively Increasing Heat Exposure

    Other intervention

    Participants complete a simulated occupational workday in which WBGT progressively increases from morning to afternoon while maintaining a mean daily WBGT of 28°C.

Treatment groups

14 Participants
are divided into 2 treatment groups
Group A: Constant Heat ExposureExperimental treatment 1 intervention
Group B: Progressively Increasing Heat ExposureExperimental treatment 1 intervention

Trial outcomes

Primary outcomes

1

Total work performed

Total work completed during each 240-minute morning and afternoon work period, expressed as cumulative minutes of treadmill walking. Each work period consists of an initial continuous walking phase until core temperature reaches 38.0°C or increases by 1.0°C above the pre-work baseline, whichever occurs first, followed by intermittent 45-min work and 15-min seated rest cycles.

Time frame
From the start to the end of the morning and afternoon work periods during each experimental trial (0-4 hours and 5-9 hours after the start of the trial, respectively).

Secondary outcomes

1

Initial stay time

Time, in minutes, from the start of continuous treadmill walking until the initial stay-time threshold is reached, defined as a core temperature of 38.0°C or an increase of 1.0°C above the pre-work baseline, whichever occurs first. Participants who do not reach the threshold during the 240-minute work period will be identified as not having reached the threshold within 240 min.

Time frame
During the initial continuous walking phase of each morning and afternoon work period.
2

Core temperature

Core temperature measured continuously using a rectal thermocouple temperature probe to assess thermoregulatory strain throughout the simulated workday.

Time frame
Continuously throughout each experimental trial, including the morning work period, lunch recovery, and afternoon work period.
3

Average core temperature during work-rest cycles

Average core temperature during the intermittent 45-min work and 15-min seated rest cycles following attainment of the initial stay-time threshold.

Time frame
During the work-rest cycles of each morning and afternoon work period.
4

Mean skin temperature

Mean skin temperature calculated from temperatures measured at eight body sites using ISO 9886 weighting factors.

Time frame
Assessed throughout each experimental trial, including the morning work period, lunch recovery, and afternoon work period.

Other outcomes

Sponsors and contacts

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