Pronostic Factors in Elderly Patients Admitted to the Intensive Care Unit for Aneurysmal Subarachnoid Hemorrhage

Trial statusNot yet recruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorCentral Hospital, Nancy, France

About this trial

Subarachnoid hemorrhage (SAH) represents a significant proportion of hemorrhagic strokes. Severe SAH in elderly patients is associated with poorer outcomes compared to younger cohorts. Better characterization of both short- and long -term prognosis in these patients is necessary to facilitate medical decision-making in the intensive care unit (ICU)

Primary Objective:

The primary objective is to identify prognostic factors associated with poor functional outcome or death at 6 months (± 2 months) in elderly patients admitted to the ICU for SAH.

Secondary Objectives:

To evaluate in-hospital mortality among elderly patients admitted to the ICU for SAH.

To describe the causes of in-hospital death (brain death, withholding/withdrawal of life-sustaining treatment \[WOLST\], other medico-surgical causes) in elderly patients admitted to the ICU for SAH.

To describe the care trajectory following hospital discharge for elderly patients admitted to the ICU for SAH.

To evaluate the mean length of stay in the ICU and in the hospital (acute care) for elderly patients admitted to the ICU for SAH.

To identify prognostic factors associated with poor functional outcome or death at 1 year in elderly patients admitted to the ICU for SAH.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Patients hospitalized in ICU for aneurysmal subarachnoid hemorrhage

Aged 70 years or over the day of admission in ICU

Between Juin 30, 2021 and Juin 30, 2025

Disqualifiers

Decline to participate

Trial population

Adult patients admitted in ICU for aneurysmal subarachnoid hemorrhage in 4 University Hospital Centers in France (CHU Nancy, CHU Reims, HC de Lyon, CHU Lille) between Juin 30, 2021 et Juin 30, 2025

Trial design

Design model

Cohort

Time perspective

Retrospective

Treatments tested in this trial

Not listed

Trial groups

170 Participants
are grouped into 1 trial group
Group A: Elderly aneurysmal SAH patients hospitalized in ICU

Trial outcomes

Primary outcomes

1

Modified Rankin Scale (MRS) et 6 months

MRS : scale from 1(no symptoms) to 6 (dead) Good outcome : 0 - 2 Bad outcome: 3 - 6 The MRS grade is either collected if already available in the medical file or estimated retrospectively based on the patient neurological evaluation.

Time frame
6 months after ICU discharge

Secondary outcomes

1

Intrahospital mortality

Intrahospital mortality = percentage of deaths occuring during the initial hospitalisation (in the ICU and the neurosurgical/neurological ward)

Time frame
Day 28
2

Cause of intrahospital death

Percentage of the following categories: cerebral death, WOLST, surgical causes and medical causes

Time frame
Day 28
3

Destination upon hospital discharge

Percentage of the following categories: Discharge to Home versus Rehabilitation Unit versus Another Inpatient Ward (non-neurosurgical)

Time frame
Day 28
4

Modified Rankin Scale upon discharge from hospital.

MRS retrieved or estimated from patient's file data at the moment of ICU or neurosurgical ward discharge.

Time frame
Day 28

Other outcomes

Sponsors and contacts

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