Proof-of-concept Study on Dyspnea Analysis Via GapCO2
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorAssistance Publique - Hôpitaux de Paris
About this trial
Patients presenting to the emergency department with acute dyspnea undergo arterial blood gas measurement and monitoring of transcutaneous capnography using the TCM5 monitor. The aim of this study is to determine whether GapCO2, the difference between transcutaneous and arterial pCO2 (PaCO2 - PtcCO2), is correlated with the congestive or non-congestive origin of dyspnea.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
Age ≥ 18 years
Patient presenting with acute dyspnea defined by a sensation of respiratory discomfort with at least one of the following criteria: RR ≥ 22 and/or SpO2 < 95%
Arterial blood gas sampling performed as part of care
Inclusion less than 1 hour after arrival time to the emergency department
Disqualifiers
Temperature greater than or equal to 37.5°C
Patient who has already received a diuretic or vasodilator treatment in the emergency department or by a prehospital medical team
Systolic blood pressure less than or equal to 100 mmHg and/or signs of peripheral hypoperfusion
Inability to express refusal to participate in the study
Trial population
Patient presenting to the emergency department of the inclusion center for acute dyspea
Trial design
Design model
Cohort
Time perspective
Prospective
Treatments tested in this trial
Not listed
Trial groups
No trial groups listed
Trial outcomes
Primary outcomes
1
GapCO2
PaCO2 measured via arterial blood gas analysis - PtcCO2 measured via TCM5 monitor, at 37°C
Time frame
Within 1 hour after enrolmentSecondary outcomes
1
Diagnostic performance of GapCO2 at 37°C
Time frame
Within 1 hour after enrolment2
Proportion of patients who underwent GapCO2 measurement among those who presented to the emergency department for dyspnea on the days of inclusion
Feasibility of measuring GapCO2 in the emergency department
Time frame
up to 28 daysSponsors and contacts
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Source ClinicalTrials.gov