Prospective Follow-up After MVA-BN Booster Vaccination
ConditionMonkeypox (Mpox)
Trial statusNot yet recruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorInstitute of Tropical Medicine, Belgium
About this trial
POQS-Boosted is a prospective observational study during which individuals who received Booster vaccination against mpox with the MVA-BN vaccine will be invited to provide biological samples at multiple times over the course of two years.
Eligibility criteria
This trial accepts healthy volunteersQualifiers
Is scheduled to receive a booster dose of MVA-BN
≥18 years
Willingness to provide written informed consent
Willingness to follow the study schedule
Disqualifiers
None
Trial population
Individuals who received MVA-BN booster vaccination will be asked to participate in "POQS-Boosted"
Trial design
Design model
Cohort
Time perspective
Prospective
Treatments tested in this trial
Not listed
Trial groups
No trial groups listed
Trial outcomes
Primary outcomes
1
Orthopoxvirus-specific serum binding and neutralising antibody titre
To describe the evolution of the orthopoxvirus-specific serum antibody response up to two years after MVA-BN booster vaccination
Time frame
from enrollment to the end of follow up at 2 yearsSecondary outcomes
1
Orthopoxvirus-specific systemic T- and B cell-mediated immune responses to MPXV
To describe the evolution of the orthopoxvirus-specific systemic cellular immune response up to two years after MVA-BN booster vaccination
Time frame
from enrollment up to 2 years2
MPXV-specific IgA in saliva and anorectal samples; T and B cell-mediated immune responses to MPXV, measured on saliva and anorectal samples
To describe the evolution of the orthopoxvirus-specific mucosal antibody \& cellular immune response up to two years after MVA-BN booster vaccination
Time frame
from enrolment up to two yearsSponsors and contacts
Click on the lead sponsor to view all of their trials.
Source ClinicalTrials.gov
This trial is not recruiting at the moment. You can still explore other options: