Prospective Geometric Analysis of Ultra-Widefield OCTA Characteristics in Central Serous Chorioretinopathy Patients
Trial statusNot yet recruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18-60
SponsorSun Yat-sen University
About this trial
By leveraging parameters including fractal dimension and topological index, we constructed a quantitative evaluation framework for ultra-widefield optical coherence tomography angiography (UWF-OCTA) images in patients with central serous chorioretinopathy (CSC), thus overcoming the limitations of conventional qualitative analysis.
Eligibility criteria
This trial accepts healthy volunteersQualifiers
Adults aged 18 to 60 years, inclusive;
Clinical diagnosis of central serous chorioretinopathy (CSC);
Completion of fundus fluorescein angiography (FFA) and indocyanine green angiography (ICGA) examinations;
Completion of ultra-widefield optical coherence tomography angiography (UWF-OCTA) imaging;
Disqualifiers
Presence of systemic diseases that may affect study outcomes or participant safety;
Pregnant or lactating women;
History of psychiatric or mental disorders that may impair compliance;
Hemorrhagic diathesis or requirement for long-term anticoagulant therapy;
Trial population
The study subjects were recruited from outpatients of the Medical Retina Department at Zhongshan Ophthalmic Center, and eligible cases meeting the study criteria were selected from the outpatient medical record system.
Trial design
Design model
Cohort
Time perspective
Prospective
Treatments tested in this trial
Not listed
Trial groups
120 Participants
are grouped into 4 trial groupsGroup A: Acute Central Serous Chorioretinopathy
Group B: Chronic Central Serous Chorioretinopathy
Group C: Recurrent Central Serous Chorioretinopathy
Group D: Control Group
Trial outcomes
Primary outcomes
1
Choroidal Vascular Fractal Dimension
Choroidal vascular fractal dimension quantified from optical coherence tomography angiography (OCTA) images.
Time frame
Baseline, 1 month, 3 months, 6 months, and 12 monthsSecondary outcomes
1
Maximum subretinal fluid height
The maximum height of subretinal fluid measured in micrometers (μm) on optical coherence tomography angiography (OCTA) images.
Time frame
Baseline, 1 month, 3 months, 6 months, and 12 months2
Subretinal fluid area
The basal area of subretinal fluid measured in square millimeters (mm²) on optical coherence tomography angiography (OCTA) images.
Time frame
Baseline, 1 month, 3 months, 6 months, and 12 months3
Subretinal fluid volume
The volume of subretinal fluid measured in cubic millimeters (mm³) on optical coherence tomography angiography (OCTA) images.
Time frame
Baseline, 1 month, 3 months, 6 months, and 12 months4
Choroidal vascular branching index
The branching index of choroidal blood vessels quantified from optical coherence tomography angiography (OCTA) images.
Time frame
Baseline, 1 month, 3 months, 6 months, and 12 monthsSponsors and contacts
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Source ClinicalTrials.gov
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