Prospective Randomized Non-Inferiority Study Comparing Natural Cycle Frozen Embryo Transfer (NC-FET) to a New Type of Endometrial Preparation for FET: Natural Proliferative Phase (NPP-FET)

ConditionComparison of Pregnancy Rate (HCG+ Level) Obtained After a Replacement Embryonic in Spontaneous Cycle and Following Protocol "NPP". Comparison

Trial statusRecruiting

Trial phaseNot listed

Trial typeObservational

Biological sexFemale

Age18-45

SponsorErasme University Hospital

About this trial

Frozen embryo replacement cycle :Two methods traditionally used: the spontaneous cycle and the artificial cycle.Now, Emergence of new protocols: NPP-FET or "Natural proliferative phase - frozen embryo transfer" Demonstrate non-inferiority between the NPP-FET and the spontaneous cycle, and superiority in terms of planning.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Single transfer Blastocyste

Disqualifiers

PGT (Preimplantation genetic diagnosis)

Testicular Sperm

Donor oocytes

Trial population

Patients with regular cycles, candidates for replacement of embryos frozen in spontaneous cycle

Trial design

Design model

Other

Time perspective

Prospective

Treatments tested in this trial

Embryo transfer
Other intervention
Frozen embryo transfer
Embryo transfer
Other intervention
Frozen Embryo transfer

Treatment groups

272 Participants

are divided into 2 treatment groups

Group A: single transfer of frozen blastocyst in natural cycle1 intervention

Group B: Natural Cycle Programmed by Progesterone1 intervention

Trial outcomes

Primary outcomes

Comparison of the pregnancy rate (Human chorionic gonadotropin hormone) (HCG+ level) obtained after spontaneous embryo replacement and following the "NPP" protocol.

Time frame

Thrugh study completion (9 months)

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Erasme University Hospital

Lead sponsor

Source ClinicalTrials.gov

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