Health TrialsbyHealthPanel

Prospective Randomized Observer Blinded Single Center Study Comparing 90-day Functional Outcome in Patients Who Received Intravenous Propofol Infusion Versus Inhalational Sevoflurane for General Anesthesia During Mechanical Thrombectomy in Patients Who Suffered From Acute Ischemic Stroke

ConditionAcute Ischemic Stroke Patients
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18+
SponsorUniversity of Kansas Medical Center

About this trial

This study is being done to compare outcomes after surgery for individuals who receive anesthesia through by inhaling medication and individuals who receive anesthesia intravenously by needle when experiencing treatment for their stroke. Currently very little is known about the outcomes for patients when comparing these two techniques of providing anesthesia during surgery. This study will provide information regarding outcomes that will help health care providers decide which technique will be better for patients

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

>18 years Acute ischemic stroke requiring endovascular treatment.

Disqualifiers

<18 years

Pregnant patients

Patients with malignant hyperthermia

Allergies or any contraindications to either inhalational or intravenous agents

Trial design

Design model

Parallel

Treatments tested in this trial

  • Anesthesia drugs during the surgery

    Procedure/Surgery

    During treatment for acute ischemic stroke, patients will be given either inhalation or intravenous anesthesia.

Treatment groups

120 Participants
are divided into 2 treatment groups
Group A: inhalational sevofluraneActive comparator 1 intervention
Group B: intravenous propofol infusionActive comparator 1 intervention

Trial outcomes

Primary outcomes

1

Functional Independence at 90 days

The primary end point is functional independence at 90 days evaluated with the modified Rankin Scale (mRS). We plan to compare the functional recovery in 90 days in patients undergoing inhalational versus intravenous general anesthesia during mechanical thrombectomy using the modified Rankin score (mRS) in patients who suffered an acute ischemic stroke. (The mRS assesses a patient's functional independence or dependence after a stroke. Scores range from 0 (no symptoms) to 6 (death), with 0-2 indicating functional independence and 3-5 indicating dependence. A separate category of 6 is often added for patients who have died)

Time frame
From enrollment to 90 days after treatment

Secondary outcomes

1

Comparison of National Institutes of Health Stroke Scale (NIHSS) score

Comparison of National Institutes of Health Stroke Scale (NIHSS) score at presentation and at 90 days between study groups.

Time frame
From enrollment to 90 days after treatment
2

Thrombolysis in Cerebral Infarction (TICI) score

Thrombolysis in Cerebral Infarction (TICI) score comparison between study groups

Time frame
From enrollment to 90 days after treatment

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

University of Kansas Medical Center

Lead sponsor

Source ClinicalTrials.gov
Apply now