This study investigates the impact of four standard of care, monitored group exercise regimens (resistance training) on conditioning and hypertrophy in women previously treated for breast cancer. The study will compare two conditioning regimens (6-12-25 and 8x8) and two hypertrophy regimens (5/5/5 cluster sets and double training) to assess changes in VO2 max, muscle mass, and fat mass.
Age 20-89 years
Women prescribed exercise as a Standard of Care
Women with a biopsy proven diagnosis of ductal carcinoma in situ (DCIS) or invasive carcinoma of the breast
Women must have undergone treatment for breast cancer, including one or more of the following: surgery, radiation therapy, chemotherapy, immunotherapy, or hormonal therapy.
Any current treatment with cytotoxic chemotherapy for breast cancer
Inability to safely engage in group sessions of resistance training as deemed by study Pl
Severe arthritic, joint, cardiovascular, or musculoskeletal condition deemed by Pl to be unsafe to engage in resistance training
Beta blocker or GLP-1 inhibitor medications
Participants will be recruited via convenience sampling from the Study Investigators' practice patient population, referrals from other physicians' practices, or identifiable medical record review (e.g., EPIC).
Cohort
Prospective
6-12-25 Training Regimen
Other interventionA conditioning regimen involving three exercises performed consecutively with minimal rest. Includes 4-6 repetitions at 4-0-1-0 tempo, 10-12 repetitions at 3-0-1-0 tempo, and 20-25 repetitions at 2-0-1-0 tempo.
8x8 Training Regimen
Other interventionA conditioning regimen optimizing high volume with short rest periods. Six exercises are performed consecutively with a 2-0-1-0 tempo and no rest between sets.
5/5/5 Cluster Set Training Regimen
Other interventionA hypertrophy regimen where an individual performs 5 repetitions at a tempo of 4 seconds during the eccentric movement of the exercise, while performing the concentric motion in 1 second then resting for 20 seconds and repeating the sequence two additional times to total three clusters of 5 repetitions.
Double Training Regimen
Other interventionA hypertrophy regimen adding an additional set of lesser repetitions for a specified exercise at the end of a tri-set of exercises.
Change in VO2 max
Change in maximal oxygen consumption (VO2 max) measured during and after each exercise regimen.
Change in Muscle and Fat Mass
Change in muscle mass and fat mass in pounds as measured by InBody 970.
Change in Muscle and Fat Mass
Change in muscle mass and fat mass in pounds as measured by ultrasound.
Change in Hand Grip Strength
Measurement of hand grip strength using a dynamometer to assess upper body strength and function.
Change in Psychology Questionnaire Scores
Assessment of psychological well-being, including confidence, motivation (intrinsic \& extrinsic), anxiety, and depression, using a Psychological Screen for Strength Training questionnaire. The responses to the variables will be calculated. The rating scale will be calculated 0-3. Not at all (0), some of the time (1), most of the time (2), and all the time (3).
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