To learn how well nitrous oxide cryoballoon ablation, a procedure that uses extreme cold to destroy abnormal tissue, works in treating flat duodenal adenomas (abnormal growths in the small intestine) in people with FAP or Lynch syndrome (HNPCC).
Participants aged 20-75 years.
Confirmed diagnosis of FAP or HNPCC.
Presence of flat duodenal adenomas confirmed by histology.
Ability to understand and willingness to sign an informed consent form.
Presence of invasive duodenal cancer.
Severe comorbidities that would contraindicate endoscopic procedures.
Allergy or intolerance to components of the nitrous oxide cryoballoon system.
Previous duodenal surgery affecting the study area.
Single group
Esophagogastroduodenoscopy
Procedure/SurgeryEsophagogastroduodenoscopy with cryoballoon ablation will be performed every 3 months to a maximum of 5 procedures.
Safety and adverse events (AEs)
Incidence of Adverse Events, Graded According to National Cancer Institute Common Terminology Criteria for Adverse Events (NCI CTCAE) Version (v) 5.0
Click on the lead sponsor to view all of their trials.
This trial is not recruiting at the moment. You can still explore other options:
