Proteomic Pattern Associated With the Diagnosis of Chronic Thromboembolic Pulmonary Hypertension
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorCentre Hospitalier Universitaire de Saint Etienne
About this trial
Chronic ThromboEmbolic Pulmonary Hypertension (CTEPH) is a rare but severe complication of pulmonary embolism (PE). CTEPH is evoked in patients with persistent dyspnea. According to international guidelines, symptomatic patients with perfusion defects on lung scan and Pulmonary Hypertension (PH)-likely transthoracic echo (TTE) must be evaluated in Pulmonary Hypertension (PH)-centers with right heart catheterism, to confirm or rule out the presence of precapillary Pulmonary Hypertension (PH), and precise the group of Pulmonary Hypertension (PH).
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
Patient with a suspicion of Chronic thromboembolic pulmonary hypertension (CTEPH) with a combination of a perfusion lung scan and transthoracic perfusion scan and transthoracic echocardiography compatible with the diagnosis (according to French recommendations)
Patients who require a right heart catheterization.
Patient affiliated or entitled to a social security plan
Patient having received informed information about the study informed about the study
Disqualifiers
Patient with a normal perfusion lung scan
Person under legal guardianship
Trial population
The study will be offered to all consecutive patients admitted to the participating competence centers, provided they meet the the study, provided they meet the inclusion criteria and have no non-inclusion criteria.
Trial design
Design model
Cohort
Time perspective
Prospective
Treatments tested in this trial
blood sample
Biological/Vaccineto realize proteomic analysis.
Treatment groups
120 Participants
are divided into 1 treatment groupGroup A: Patient with suspicion of Chronic ThromboEmbolic Pulmonary Hypertension (CTEPH)1 intervention
Trial outcomes
Primary outcomes
1
Proteomic pattern associated with the diagnosis of Chronic thromboembolic pulmonary hypertension (CTEPH)
Analysis of the final diagnosis retained for the patient : Chronic thromboembolic pulmonary hypertension (CTEPH) (population of interest), pre-capillary Pulmonary Hypertension (PH) other than Chronic thromboembolic pulmonary hypertension (CTEPH), post-capillary Pulmonary Hypertension (PH), no Pulmonary Hypertension (PH).
Time frame
Day: 0Secondary outcomes
1
Analysis of recording of hemodynamic data at diagnosis
hemodynamic data : pulmonary vascular resistance, cardiac index, pulmonary arterial pressures
Time frame
Day: 02
Analysis of recording of hemodynamic data at diagnosis
hemodynamic data : pulmonary vascular resistance,
Time frame
Day: 03
Analysis of recording of hemodynamic data at diagnosis
hemodynamic data : cardiac index
Time frame
Day: 04
Analysis of recording of hemodynamic data at diagnosis
hemodynamic data : pulmonary arterial pressures
Time frame
Day: 0Sponsors and contacts
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Source ClinicalTrials.gov