Health TrialsbyHealthPanel

PRP Plus Fractional CO₂ Laser for Acne Scars

ConditionsPost-Acne Atrophic ScarsCarbon Dioxide LasersPlatelet-Rich Plasma
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-40
SponsorGujranwala medical college District Headquarters Hospital, Gujranwala

About this trial

This randomized controlled trial aims to evaluate whether adding platelet-rich plasma (PRP) to fractional CO₂ laser resurfacing improves the treatment of moderate-to-severe acne scars compared with laser alone. Seventy adults aged 18-40 years will be recruited from the Dermatology Department of Gujranwala Medical College Teaching Hospital. Participants will be randomly assigned to receive either fractional CO₂ laser combined with topical PRP or fractional CO₂ laser alone, with three treatment sessions delivered four weeks apart.

The primary outcome is the change in acne scar severity measured using the Goodman and Baron Quantitative Acne Scar Scale. Secondary outcomes include redness, edema, pain scores, and patient satisfaction assessed using Likert and numeric rating scales. The study is single-blinded, with patients unaware of treatment allocation. PRP will be prepared using a standardized double-spin centrifugation process. Data will be analyzed using appropriate statistical tests with a significance level of p \< 0.05. The study aims to determine whether PRP enhances laser efficacy, reduces side effects, and improves patient-reported outcomes.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

None

Disqualifiers

None

Trial design

Design model

Parallel

Treatments tested in this trial

  • Fractional CO₂ Laser + Platelet-Rich Plasma (PRP)

    Procedure/Surgery

    Fractional CO₂ Laser + Platelet-Rich Plasma (PRP) Participants receive fractional CO₂ laser treatment followed by topical application of autologous platelet-rich plasma. Three treatment sessions are performed at four-week intervals. PRP is prepared using a standardized double-spin centrifugation method from 10 mL of the participant's blood. After laser resurfacing, the PRP is applied immediately to the treated area to enhance healing and collagen remodeling.

  • Fractional CO₂ Laser Only

    Procedure/Surgery

    Fractional CO₂ Laser Only Participants receive fractional CO₂ laser treatment alone, with the same laser settings and treatment schedule as the intervention group. Three sessions are performed at four-week intervals. To maintain participant blinding, a placebo-filled syringe covered with opaque tape is applied to the skin without delivering PRP.

Treatment groups

70 Participants
are divided into 2 treatment groups
Group A: Laser + PRP armExperimental treatment 1 intervention
Group B: Laser only armExperimental treatment 1 intervention

Trial outcomes

Primary outcomes

1

Change in Acne Scar Severity (Goodman and Baron Quantitative Acne Scar Scale)

Acne scar severity will be assessed using the Goodman and Baron Quantitative Acne Scar Scale, which grades scars based on type, number of lesions, and affected surface area. Scores will be recorded at baseline and at each follow-up visit to measure improvement over the course of treatment.

Time frame
12weeks

Secondary outcomes

1

Redness (Erythema) Score

Redness will be evaluated by the assessor using a 4-point Likert scale (0 = none, 1 = mild, 2 = moderate, 3 = severe) at each visit to assess post-laser inflammatory response.

Time frame
12weeks
2

Edema (Swelling) Score

Edema will be assessed by the evaluator using a 4-point Likert scale ranging from 0 (none) to 3 (severe) to evaluate treatment-related swelling.

Time frame
12 weeks
3

Pain Score (11-Point Numeric Rating Scale)

Participants will report pain intensity using an 11-point numeric scale (0 = no pain; 10 = worst possible pain) during and after each treatment session.

Time frame
12 weeks
4

Patient Satisfaction Rating

Patient satisfaction with treatment outcome will be measured using a 4-point Likert scale (0 = not satisfied; 1 = neutral; 2 = satisfied; 3 = very satisfied). Standardized digital photographs will be used to assist patient self-evaluation.

Time frame
12 weeks

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Gujranwala medical college District Headquarters Hospital, Gujranwala

Lead sponsor

Saglik Bilimleri Universitesi

Collaborator

Source ClinicalTrials.gov
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