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Pulse Wave Transit Time After Infraclavicular Block

ConditionInfraclavicular Brachial Plexus Block
Trial statusNot yet recruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18-65
SponsorSakarya University

About this trial

This prospective observational study aims to evaluate the time-dependent changes in Pulse Wave Transit Time (PWTT) following ultrasound-guided infraclavicular brachial plexus block. PWTT is a non-invasive hemodynamic parameter reflecting vascular tone and sympathetic nervous system activity. Patients undergoing upper extremity surgery under infraclavicular block will be monitored using standard perioperative monitoring devices. PWTT measurements will be obtained before and after block placement at predefined time intervals. Secondary outcomes will include perfusion index, skin temperature, heart rate, blood pressure, respiratory rate, and oxygen saturation. The study seeks to determine whether PWTT can serve as an objective and non-invasive marker of sympathetic blockade following infraclavicular block.

Eligibility criteria

This trial accepts healthy volunteers

Qualifiers

Patients undergoing elective upper extremity hand surgery

18 - 65 years

ASA I

No coagulopathy, thrombocytopenia, coagulation disorders

Disqualifiers

History of drug allergy relevant to study procedures or local anesthetics

Body mass index (BMI) ≥ 30 kg/m²

Body weight < 40 kg

Age < 18 years or > 65 years

Trial population

The study population will consist of adult patients aged 18-65 years with ASA physical status I who are scheduled to undergo elective upper extremity hand surgery under ultrasound-guided infraclavicular brachial plexus block. All participants will receive standard-of-care anesthesia management. Patients with contraindications to peripheral nerve block, significant systemic disease, obesity (BMI ≥30 kg/m²), coagulation disorders, opioid use, or conditions affecting sympathetic activity will be excluded. Only patients who provide informed consent will be enrolled.

Trial design

Design model

Cohort

Time perspective

Prospective

Treatments tested in this trial

  • Ultrasound-guided infraclavicular brachial plexus block

    Procedure/Surgery

    Ultrasound-guided infraclavicular brachial plexus block will be performed as part of routine clinical anesthesia practice for upper extremity surgery. Local anesthetic will be administered according to standard institutional protocols. No additional or experimental drug or procedure will be applied for research purposes. Pulse Wave Transit Time (PWTT) and other hemodynamic parameters will be recorded before and after block placement at predefined time intervals.

Treatment groups

25 Participants
are divided into 1 treatment group
Group A: Infraclavicular Block Group1 intervention

Trial outcomes

Primary outcomes

1

Change in Pulse Wave Transit Time

The primary outcome is the time-dependent change in Pulse Wave Transit Time (PWTT) following ultrasound-guided infraclavicular brachial plexus block. PWTT will be measured as the interval between the R-wave of the electrocardiogram (ECG) and the corresponding pulse wave detected by peripheral pulse oximetry. Measurements will be recorded at baseline (pre-block) and at 0, 5, 10, 15, and 20 minutes after block placement. The primary analysis will evaluate the change in PWTT over time within the blocked extremity.

Time frame
20 minutes after infraclavicular block

Secondary outcomes

1

Perfusion Index

Changes in perfusion index (PI) measured from the pulse oximeter at the blocked and contralateral upper extremities at baseline and at 0, 5, 10, 15, and 20 minutes after infraclavicular block.

Time frame
20 minutes after infraclavicular block
2

Skin Temperature

Changes in skin temperature of the blocked and contralateral upper extremities measured at baseline and at 0, 5, 10, 15, and 20 minutes after block placement.

Time frame
20 minutes after infraclavicular block
3

oxygen saturation

Changes in peripheral oxygen saturation measured using pulse oximetry during the study period.

Time frame
20 minutes after infraclavicular block

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Sakarya University

Lead sponsor

Source ClinicalTrials.gov

This trial is not recruiting at the moment. You can still explore other options: