QUAD-HF - Prospective Registry of Patients With Incident Heart Failure and Left Ventricular Ejection Fraction <50%

ConditionHeart Failure
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorMid and South Essex NHS Foundation Trust

About this trial

The QUAD-HF registry is an observational study that would enroll patients in the United Kingdom, who have been newly diagnosed with heart failure and a left ventricular ejection fraction \<50%. We plan to assess clinical outcomes in these patients, such as hospitalization and death, in relation to their diagnosis, implementation of guidelines and type of treatments these patients have received.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Age >18 years

Newly diagnosed Heart Failure with a Left Ventricular Ejection Fraction <50% (≤12 Weeks prior to enrolment).

Able and willing to consent.

Disqualifiers

LVEF 50% or more at time of diagnosis

Palliative care

Unable or unwilling to give consent

Trial population

Eligible participants would include adult patients (\>18 years) attending HF clinics in hospital or community settings or those hospitalized for the management of Acute Decompensated Heart failure (ADHF), who have been newly diagnosed HF with a left ventricular ejection fraction of \<50%, no more than 12 weeks prior. Patients would be excluded if they have had a previous diagnosis of heart failure, are on a palliative care pathway or are unable or unwilling to consent.

Trial design

Design model

Cohort

Time perspective

Prospective

Treatments tested in this trial

Not listed

Trial groups

No trial groups listed

Trial outcomes

Primary outcomes

1

Cardiovascular Mortality or Hospitalization for Heart Failure

Death due to cardiac causes or hospitalization due to worsening heart failure symptoms

Time frame
From enrolment to 12 months after diagnosis

Secondary outcomes

1

All-cause mortality

Death due to any cause

Time frame
From enrolment to 12 months after diagnosis
2

Cardiovascular Mortality

Death due to cardiac causes

Time frame
From enrolment to 12 months after diagnosis
3

Hospitalization for Heart Failure

Hospitalization due to worsening heart failure symptoms

Time frame
From enrolment to 12 months after diagnosis

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Mid and South Essex NHS Foundation Trust

Lead sponsor

Anglia Ruskin University

Collaborator

British Society for Heart Failure

Collaborator