Allotransplants of vascularized composite tissues are subject to chronic vascular rejection, which can lead to graft loss. Currently, no imaging technique allows a reproducible quantitative exploration of the arterial trees of the hand, and therefore a satisfactory monitoring of transplants. Since 2014, flow MRI has been applied to the analysis of small-calibre arteries by the Image Processing Team at the Amiens-Picardie University Hospital. Between 2015 and 2017, several acquisitions were made in 3 patients who received facial allotransplantation, and the team recently developed a flow MRI protocol dedicated to the study of arterial trees in the hand.
The main objective is to measure vascular flows of radial, ulnar and interdigital arterial trees in normal (healthy volunteers) and pathological situations (patients with radial forearm flap reconstruction and patients with hand allotransplantation) using the specifically developed flow MRI protocol.
Adult (≥ 18 years old)
patients who has received appropriate information and provided informed consent
patients benefiting from social security insurance
patients with no contraindications to magnetic resonance imaging
Person with a contraindication to MRI
pregnant or breastfeeding woman
minors (< 18 years)
person under guardianship or deprived of liberty by a judicial or administrative decision
Parallel
MRI acquisitions
Other interventionMRI acquisitions will be performed on the ACHIEVA 3T TX DStream Philips® Research MRI of the GIE Faire Faces.
Doppler ultrasound procedure
Other interventionThe Doppler ultrasound procedure will be conducted in the traditional way in the Vascular Medicine Department of the Amiens-Picardie University Hospital
Variation of radial vascular flows between healthy volunteers and patients with forearm flap reconstruction
Radial vascular flows between healthy volunteers and patients with forearm flap reconstruction will be determined by using the specifically developed flow MRI protocol
Variation of ulnar artery vascular flows between healthy volunteers and patients with forearm flap reconstruction
Ulnar artery vascular flows between healthy volunteers and patients with forearm flap reconstruction will be determined by using the specifically developed flow MRI protocol
Variation of interdigital arterial tree vascular flows between healthy volunteers and patients with forearm flap reconstruction
Interdigital arterial tree vascular flows between healthy volunteers and patients with forearm flap reconstruction will be determined by using the specifically developed flow MRI protocol
Variation of radial vascular flows between healthy volunteers and patients with hand allotransplantation
Radial vascular flows between healthy volunteers and patients with hand allotransplantation will be determined by using the specifically developed flow MRI protocol
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Centre Hospitalier Universitaire, Amiens
Lead sponsor
Hôpital Edouard Herriot
Collaborator
