Quantitative T1rho Magnetic Resonance Imaging in Healthy Subjects
ConditionMagnetic Resonance Imaging
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18+
SponsorChinese University of Hong Kong
About this trial
T1rho imaging is a new MRI technique that has strong potential in neuroimaging. This technique does not require exogenous contrast agents and has high spatial resolution.
In this study we aim to characterise the normal appearance of T1rho in the brain parenchyma in healthy participants. T1rho values will be measured in normal brain structures.
Eligibility criteria
This trial accepts healthy volunteersQualifiers
None
Disqualifiers
Subjects with a contraindication to magnetic resonance imaging such as the presence of metallic implants, claustrophobia and pregnancy.
Subjects with previous severe allergic or anaphylactoid reaction to a gadolinium contrast agent, or contraindication to contrast gadolinium administration, such severe renal disease or acutely deteriorating renal function, who would be at risk of nephrogenic systemic fibrosis
Subjects who are unable to tolerate the scan without moving the head as a result of symptoms such as tremor, spasticity, involuntary movements and spasms, cognitive impairment, coughing, and shortness of breath.
Trial design
Design model
Single group
Treatments tested in this trial
T1rho imaging
Diagnostic testMagnetic Resonance Imaging using T1rho
Treatment groups
30 Participants
are divided into 1 treatment groupGroup A: T1rho MRIExperimental treatment 1 intervention
Trial outcomes
Primary outcomes
1
T1rho value in normal grey and white matter in healthy volunteers
T1rho value (measured on T1rho weighted MRI) in normal grey and white matter in healthy volunteers
Time frame
Up to 2 monthsSponsors and contacts
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Source ClinicalTrials.gov